Prognostic Value of Textural Indices Extracted from Pretherapeutic 18-F FDG-PET/CT in Head and Neck Squamous Cell Carcinoma

Overview

Journal Head Neck

Specialties General Surgery
Oncology

Date 2018 Dec 15

PMID 30549149

Citations 23

Authors

Catherine Guezennec

Philippe Robin

Fanny Orlhac

David Bourhis

Olivier Delcroix

Yves Gobel

Jean Rousset

Ulrike Schick

Pierre-Yves Salaun

Ronan Abgral

Affiliations

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Abstract

Background: This study aimed at assessing the prognostic value of textural indices extracted from 18F-fluorodeoxyglucose positron-emission tomography (FDG-PET)/CT in a large cohort of patients with head and neck squamous cell carcinomas (HNSCC) of any anatomic subsite and staging.

Methods: Consecutive patients with HNSCC referred for a pretreatment FDG-PET/CT were retrospectively included and followed up for a minimum of 2 years. Standardized uptake value, metabolic tumor volume (MTV), and textural indices were calculated using LIFEx software. Prognostic significance of parameters was assessed in univariate and multivariate analysis.

Results: Textural indices were extracted in 284 patients (mean age = 63.7±9.6 years). In univariate analysis, MTV and 4 textural indices-Correlation, Entropy, Energy, and Coarseness-were significantly correlated with overall survival (OS). In multivariate analysis, MTV (P = .008) and Correlation (P = .028) remained independently correlated to OS.

Conclusion: This study showed that MTV and 1 textural index extracted from pretherapeutic FDG-PET/CT (Correlation) were independent prognostic factors of OS in patients with HNSCC.

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