MicroRNA-34a Inhibits Metastasis in Liver Cancer Cells

Overview

Journal Oncol Lett

Specialty Oncology

Date 2018 Dec 15

PMID 30546428

Citations 10

Authors

Wei Wei

Huihuan Tang

Ling Tang

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNA/miRs) have the ability to target specific mRNAs, resulting in degradation of mRNA or inhibition of translation. Notably, miR-34a is able to regulate cell cycle and tumorigenicity. The level of miR-34a expression is usually low in tumors, and previous studies have indicated miR-34a to be an important tumor suppressor. In order to elucidate the association between miR-34a and metastasis, stable cell lines were established and transfected with miR-34a. Cell invasion assay was subsequently performed. The present study demonstrated that cell invasion was inhibited in cells that were transfected with miR-34a compared with the control group (P<0.05). Therefore, miR-34a was able to inhibit metastasis in liver cancer cells.

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