MiR-639 is Associated with Advanced Cancer Stages and Promotes Proliferation and Migration of Nasopharyngeal Carcinoma

Overview

Journal Oncol Lett

Specialty Oncology

Date 2018 Dec 15

PMID 30546422

Citations 5

Authors

Yun-Hui Wang

Yan-Wei Yin

Han Zhou

Yuan-Dong Cao

Affiliations

Soon will be listed here.

Abstract

Early detection of nasopharyngeal carcinoma (NPC) is of vital importance for improving prognosis and survival rates. MicroRNA (miRNA) are a class of short and non-coding RNA molecules that are capable of inhibiting the translation of mRNA of target genes. Previous studies have revealed that miRNA are involved in tumorigenesis and cancer development. The RNase-resistance of circulating miRNA have made them valuable non-invasive biomarkers, and has therefore drawn particular attention to their therapeutic potential. The aim of the present study was to investigate the expression of the previously uncharacterized miR-639 in NPC. In a study population of 139 patients, higher expression of miR-639 was associated with metastasis, more advanced cancer stages, and lower disease-free survival rates. experiments involving transfection of human NPC C666-1 and NPC/HK1 cell lines with miR-639 mimics and antagomir indicated that overexpressing miR-639 promoted cell proliferation and migration, suppression of miR-639 inhibited proliferation and migration. The present study provides evidence that miR-639 is differentially expressed in NPC tissues of varying cancer stages, and suggests that quantifying circulating miR-639 may be of importance for non-invasive diagnosis and prognostic evaluation, and may have potential therapeutic utility.

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References

Liu N, Chen N, Cui R, Li W, Li Y, Wei R . Prognostic value of a microRNA signature in nasopharyngeal carcinoma: a microRNA expression analysis. Lancet Oncol. 2012; 13(6):633-41. DOI: 10.1016/S1470-2045(12)70102-X. View

Giordano S, Columbano A . MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma?. Hepatology. 2012; 57(2):840-7. DOI: 10.1002/hep.26095. View

ODonnell K, Wentzel E, Zeller K, Dang C, Mendell J . c-Myc-regulated microRNAs modulate E2F1 expression. Nature. 2005; 435(7043):839-43. DOI: 10.1038/nature03677. View

Nordentoft I, Birkenkamp-Demtroder K, Agerbaek M, Theodorescu D, Stampe Ostenfeld M, Hartmann A . miRNAs associated with chemo-sensitivity in cell lines and in advanced bladder cancer. BMC Med Genomics. 2012; 5:40. PMC: 3473298. DOI: 10.1186/1755-8794-5-40. View

Bakir M, Millington K, Soysal A, Deeks J, Efee S, Aslan Y . Prognostic value of a T-cell-based, interferon-gamma biomarker in children with tuberculosis contact. Ann Intern Med. 2008; 149(11):777-87. PMC: 2730556. DOI: 10.7326/0003-4819-149-11-200812020-00248. View

Liu X, Luo H, Tian W, Lu J, Li G, Wang L . Diagnostic and prognostic value of plasma microRNA deregulation in nasopharyngeal carcinoma. Cancer Biol Ther. 2013; 14(12):1133-42. PMC: 3912036. DOI: 10.4161/cbt.26170. View

Orom U, Nielsen F, Lund A . MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. Mol Cell. 2008; 30(4):460-71. DOI: 10.1016/j.molcel.2008.05.001. View

Schickel R, Boyerinas B, Park S, Peter M . MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene. 2008; 27(45):5959-74. DOI: 10.1038/onc.2008.274. View

Pasquinelli A . MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet. 2012; 13(4):271-82. DOI: 10.1038/nrg3162. View

10.

Spring K, Fournier P, Lapointe L, Chabot C, Roussy J, Pommey S . The protein tyrosine phosphatase DEP-1/PTPRJ promotes breast cancer cell invasion and metastasis. Oncogene. 2015; 34(44):5536-47. DOI: 10.1038/onc.2015.9. View

11.

Salim H, Akbar N, Zong D, Vaculova A, Lewensohn R, Moshfegh A . miRNA-214 modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence. Br J Cancer. 2012; 107(8):1361-73. PMC: 3494421. DOI: 10.1038/bjc.2012.382. View

12.

Sebova K, Zmetakova I, Bella V, Kajo K, Stankovicova I, Kajabova V . RASSF1A and CDH1 hypermethylation as potential epimarkers in breast cancer. Cancer Biomark. 2012; 10(1):13-26. DOI: 10.3233/CBM-2012-0230. View

13.

Gomes C, de Sousa S, Gomez R . MicroRNAs: small molecules with a potentially role in oral squamous cell carcinoma. Curr Pharm Des. 2012; 19(7):1285-91. DOI: 10.2174/138161213804805694. View

14.

Gao M, Yin H, Fei Z . Clinical application of microRNA in gastric cancer in Eastern Asian area. World J Gastroenterol. 2013; 19(13):2019-27. PMC: 3623978. DOI: 10.3748/wjg.v19.i13.2019. View

15.

McDermott A, Dutt S, Watkinson J . The aetiology of nasopharyngeal carcinoma. Clin Otolaryngol Allied Sci. 2001; 26(2):82-92. DOI: 10.1046/j.1365-2273.2001.00449.x. View

16.

Lai S, Li W, Chen L, Luo W, Chen Y, Liu L . How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients?. Int J Radiat Oncol Biol Phys. 2010; 80(3):661-8. DOI: 10.1016/j.ijrobp.2010.03.024. View

17.

Wu S, Huang S, Ding J, Zhao Y, Liang L, Liu T . Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. Oncogene. 2010; 29(15):2302-8. DOI: 10.1038/onc.2010.34. View

18.

Ma J, Mai H, Hong M, Cui N, Lu T, Lu L . Is the 1997 AJCC staging system for nasopharyngeal carcinoma prognostically useful for Chinese patient populations?. Int J Radiat Oncol Biol Phys. 2001; 50(5):1181-9. DOI: 10.1016/s0360-3016(01)01537-1. View

19.

Liu J, Valencia-Sanchez M, Hannon G, Parker R . MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol. 2005; 7(7):719-23. PMC: 1855297. DOI: 10.1038/ncb1274. View

20.

Ralph D, Zhao L, Aston C, Manjeshwar S, Pugh T, DeFreese D . Age-specific association of steroid hormone pathway gene polymorphisms with breast cancer risk. Cancer. 2007; 109(10):1940-8. DOI: 10.1002/cncr.22634. View