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Small Cell Lung Cancer Transformation As a Mechanism of Resistance to PD-1 Therapy in KRAS-Mutant Lung Adenocarcinoma: A Report of Two Cases

Overview
Journal J Thorac Oncol
Publisher Elsevier
Date 2018 Dec 14
PMID 30543839
Citations 23
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References
1.
Sutherland K, Proost N, Brouns I, Adriaensen D, Song J, Berns A . Cell of origin of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung. Cancer Cell. 2011; 19(6):754-64. DOI: 10.1016/j.ccr.2011.04.019. View

2.
Imakita T, Fujita K, Kanai O, Terashima T, Mio T . Small cell lung cancer transformation during immunotherapy with nivolumab: A case report. Respir Med Case Rep. 2017; 21:52-55. PMC: 5376266. DOI: 10.1016/j.rmcr.2017.03.019. View

3.
Norkowski E, Ghigna M, Lacroix L, Le Chevalier T, Fadel E, Dartevelle P . Small-cell carcinoma in the setting of pulmonary adenocarcinoma: new insights in the era of molecular pathology. J Thorac Oncol. 2014; 8(10):1265-71. DOI: 10.1097/JTO.0b013e3182a407fa. View

4.
Lee J, Lee J, Kim S, Kim S, Youk J, Park S . Clonal History and Genetic Predictors of Transformation Into Small-Cell Carcinomas From Lung Adenocarcinomas. J Clin Oncol. 2017; 35(26):3065-3074. DOI: 10.1200/JCO.2016.71.9096. View

5.
Oser M, Niederst M, Sequist L, Engelman J . Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin. Lancet Oncol. 2015; 16(4):e165-72. PMC: 4470698. DOI: 10.1016/S1470-2045(14)71180-5. View