» Articles » PMID: 30542721

Anticancer Activity of Gomisin J from Schisandra Chinensis Fruit

Overview
Journal Oncol Rep
Specialty Oncology
Date 2018 Dec 14
PMID 30542721
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

In attempting to identify effective anticancer drugs from natural products that are harmless to humans, we found that the gomisin J from Schisandra chinensis fruit has anticancer activity. Schisandra chinensis fruits are used in traditional herbal medicine and gomisin J is one of their chemical constituents. In the present study, we examined the anticancer activity of gomisin J in MCF7 and MDA-MB-231 breast cancer cell lines and in MCF10A normal cell line, in a time- and concentration-dependent manner. Our data revealed that gomisin J exerted a much stronger cytotoxic effect on MCF7 and MDA-MB-231 cancer cells than on MCF10A normal cells. Gomisin J suppressed the proliferation and decreased the viability of MCF7 and MDA-MB-231 cells at relatively low (<10 µg/ml) and high (>30 µg/ml) concentrations, respectively. Our data also revealed that gomisin J induced necroptosis, a programmed form of necrosis, as well as apoptosis. Notably, gomisin J predominantly induced necroptosis in MCF7 cells that are known to have high resistance to many pro-apoptotic anticancer drugs, while MDA-MB-231 exhibited a much lower level of necroptosis but instead a higher level of apoptosis. This data indicated the possibility that it may be used as a more effective anticancer drug, especially in apoptosis-resistant malignant cancer cells. In an extended study, gomisin J exhibited a strong cytotoxic effect on all tested various types of 13 cancer cell lines, indicating its potential to be used against a wide range of different types of cancer cells.

Citing Articles

Phytochemical Profiling and Biological Activities of Extracts from Bioreactor-Grown Suspension Cell Cultures of .

Jafernik K, Kokotkiewicz A, Dziurka M, Kruk A, Hering A, Jedrzejewski K Molecules. 2024; 29(22).

PMID: 39598649 PMC: 11596403. DOI: 10.3390/molecules29225260.


Inhibitory effect of benzocaine from Schisandra chinensis on Alternaria alternata.

Long L, Zhao Q, Zhang F, Tang R, Wei J, Guan S Sci Rep. 2024; 14(1):6691.

PMID: 38509170 PMC: 10954763. DOI: 10.1038/s41598-024-57237-1.


Comprehensive review of dibenzocyclooctadiene lignans from the Schisandra genus: anticancer potential, mechanistic insights and future prospects in oncology.

Jafernik K, Motyka S, Calina D, Sharifi-Rad J, Szopa A Chin Med. 2024; 19(1):17.

PMID: 38267965 PMC: 10809469. DOI: 10.1186/s13020-024-00879-0.


Integration of full-length transcriptomes and anthocyanin metabolite analysis for understanding fruit coloration mechanism in .

Li H, Fan C, Liu J, Wang B, Li H Physiol Mol Biol Plants. 2022; 28(5):921-933.

PMID: 35722508 PMC: 9203629. DOI: 10.1007/s12298-022-01179-3.


Anti-Cancer Effects of α-Cubebenoate Derived from in CT26 Colon Cancer Cells.

Gong J, Kim J, Lee S, Choi Y, Jin Y, Choi Y Molecules. 2022; 27(3).

PMID: 35164001 PMC: 8839175. DOI: 10.3390/molecules27030737.