Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2018 Dec 12

PMID 30532778

Citations 6

Authors

Qin-Fen Chen

Dan Cao

Ting-Ting Ye

Hui-Hui Deng

Hong Zhu

Affiliations

Soon will be listed here.

Abstract

Background: The present study is undertaken to investigate the fibrinogen levels in type 2 diabetes mellitus (T2DM) and its relation to peripheral artery disease (PAD) based on a more accurate and applied noninvasive measurements of duplex ultrasonography.

Methods: We performed a cross-sectional study including 1096 T2DM patients (474 males and 622 females). The odds ratios (ORs) and 95% confidence intervals (CIs) were presented to show the association between PAD and fibrinogen in the subjects divided by fibrinogen levels quarterly. Furthermore, the univariate and multiple logistic analyses were performed to explore the correlation between PAD and fibrinogen levels, individual components in the cross-sectional study.

Results: Finally, 887 (80.9%) T2DM patients meet the diagnostic criteria of PAD and these patients had considerably higher serum fibrinogen concentration than non-PAD group ( < 0.001). Multiple logistic analyses revealed that higher fibrinogen quartiles were positively related with the development of PAD in the adjusted model. After adjusting for known confounding parameters, the ORs for PAD were 1.993 (95% CI: 1.322-3.005, < 0.001), 2.469 (95% CI: 1.591-3.831, < 0.001), and 2.942 (95% CI, 1.838-4.711, < 0.001) for Q2, Q3, and Q4, respectively (all values <0.05).

Conclusions: Our results suggest that serum fibrinogen concentration can be considered as an independent risk factor for PAD in T2DM patients.

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References

Dormandy J, Heeck L, Vig S . Lower-extremity arteriosclerosis as a reflection of a systemic process: implications for concomitant coronary and carotid disease. Semin Vasc Surg. 2000; 12(2):118-22. View

Poulsen M, Nybo M, Dahl J, Hosbond S, Poulsen T, Johansen A . Plasma osteoprotegerin is related to carotid and peripheral arterial disease, but not to myocardial ischemia in type 2 diabetes mellitus. Cardiovasc Diabetol. 2011; 10:76. PMC: 3163516. DOI: 10.1186/1475-2840-10-76. View

Schmieder F, Comerota A . Intermittent claudication: magnitude of the problem, patient evaluation, and therapeutic strategies. Am J Cardiol. 2001; 87(12A):3D-13D. DOI: 10.1016/s0002-9149(01)01671-x. View

Jain A, Gupta H, Narayan S . Hyperfibrinogenemia in patients of diabetes mellitus in relation to glycemic control and urinary albumin excretion rate. J Assoc Physicians India. 2001; 49:227-30. View

Tendera M, Aboyans V, Bartelink M, Baumgartner I, Clement D, Collet J . ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries: the Task Force on the Diagnosis and.... Eur Heart J. 2011; 32(22):2851-906. DOI: 10.1093/eurheartj/ehr211. View

Bak E, Marcisz C, Kadlubowska M, Michalik A, Krawczyk B, Dobrzyn-Matusiak D . Independent Factors of Changes of Ankle-Brachial Index in Peripheral Arterial Occlusive Disease in Elderly Patients with or without Diabetes. Int J Environ Res Public Health. 2016; 13(11). PMC: 5129313. DOI: 10.3390/ijerph13111103. View

Fuller J, Keen H, Jarrett R, Omer T, Meade T, Chakrabarti R . Haemostatic variables associated with diabetes and its complications. Br Med J. 1979; 2(6196):964-6. PMC: 1596588. DOI: 10.1136/bmj.2.6196.964. View

Sekiya N, Ichioka S . Efficacy of Ultrasonography at the Ankle Level for Estimation of Pedal Microcirculation. Ann Vasc Dis. 2015; 8(3):198-202. PMC: 4575330. DOI: 10.3400/avd.oa.15-00078. View

Sacco R, Kasner S, Broderick J, Caplan L, Connors J, Culebras A . An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013; 44(7):2064-89. PMC: 11078537. DOI: 10.1161/STR.0b013e318296aeca. View

10.

Burbelko M, Augsten M, Kalinowski M, Heverhagen J . Comparison of contrast-enhanced multi-station MR angiography and digital subtraction angiography of the lower extremity arterial disease. J Magn Reson Imaging. 2012; 37(6):1427-35. DOI: 10.1002/jmri.23944. View

11.

Wu T, Ou H, Chou C, Hsiao S, Lin C, Kao P . Decrease in inflammatory cardiovascular risk markers in hyperlipidemic diabetic patients treated with fenofibrate. Ann Clin Lab Sci. 2007; 37(2):158-66. View

12.

Cooke J, Wilson A . Biomarkers of peripheral arterial disease. J Am Coll Cardiol. 2010; 55(19):2017-23. PMC: 3157958. DOI: 10.1016/j.jacc.2009.08.090. View

13.

Imperatore G, Riccardi G, Iovine C, Rivellese A, Vaccaro O . Plasma fibrinogen: a new factor of the metabolic syndrome. A population-based study. Diabetes Care. 1998; 21(4):649-54. DOI: 10.2337/diacare.21.4.649. View

14.

Shareghi S, Gopal A, Gul K, Matchinson J, Wong C, Weinberg N . Diagnostic accuracy of 64 multidetector computed tomographic angiography in peripheral vascular disease. Catheter Cardiovasc Interv. 2009; 75(1):23-31. DOI: 10.1002/ccd.22228. View

15.

Ota H, Takase K, Igarashi K, Chiba Y, Haga K, Saito H . MDCT compared with digital subtraction angiography for assessment of lower extremity arterial occlusive disease: importance of reviewing cross-sectional images. AJR Am J Roentgenol. 2003; 182(1):201-9. DOI: 10.2214/ajr.182.1.1820201. View

16.

Lowe G, Rumley A . Fibrinogen and its degradation products as thrombotic risk factors. Ann N Y Acad Sci. 2001; 936:560-5. DOI: 10.1111/j.1749-6632.2001.tb03544.x. View

17.

Davalos D, Akassoglou K . Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol. 2011; 34(1):43-62. DOI: 10.1007/s00281-011-0290-8. View

18.

Ouwendijk R, de Vries M, Stijnen T, Pattynama P, van Sambeek M, Buth J . Multicenter randomized controlled trial of the costs and effects of noninvasive diagnostic imaging in patients with peripheral arterial disease: the DIPAD trial. AJR Am J Roentgenol. 2008; 190(5):1349-57. DOI: 10.2214/AJR.07.3359. View

19.

de Vries S, Hunink M, Polak J . Summary receiver operating characteristic curves as a technique for meta-analysis of the diagnostic performance of duplex ultrasonography in peripheral arterial disease. Acad Radiol. 1996; 3(4):361-9. DOI: 10.1016/s1076-6332(96)80257-1. View

20.

Pacilli A, De Cosmo S, Trischitta V, Bacci S . Role of relationship between HbA1c, fibrinogen and HDL-cholesterol on cardiovascular disease in patients with type 2 diabetes mellitus. Atherosclerosis. 2013; 228(1):247-8. DOI: 10.1016/j.atherosclerosis.2013.02.010. View