FoxG1 Directly Represses Dentate Granule Cell Fate During Forebrain Development

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2018 Dec 12

PMID 30532694

Citations 5

Authors

Xiao Han

Xiaochun Gu

Qianqian Zhang

Qingxia Wang

Yao Cheng

Samuel J Pleasure

Chunjie Zhao

Affiliations

Soon will be listed here.

Abstract

The cortex consists of 100s of neuronal subtypes that are organized into distinct functional regions; however, the mechanisms underlying cell fate determination remain unclear. is involved in several developmental processes, including telencephalic patterning, cell proliferation and cell fate determination. Constitutive disruption of leads to the transformation of cortical neurons into Cajal-Retzius (CR) cells, accompanied by a substantial expansion of the cortical hem through the consumption of the cortex. However, rather than the induction of a cell fate switch, another group has reported a large lateral to medial repatterning of the developing telencephalon as the explanation for this change in cell type output. Here, we conditionally disrupted in telencephalic progenitor cells by crossing mice with mice combined with tamoxifen (TM) induction at distinct developmental stages beginning at E10.5 to further elucidate the role of FoxG1 in cell fate determination after telencephalon pattern formation. The number of dentate gyrus (DG) granule-like cells was significantly increased in the cortex. The increase was even detected after deletion at E14.5. mosaic deletion and cell culture further revealed a cell-autonomous role for FoxG1 in repressing granule cell fate. However, the cortical hem, which is required for the patterning and the development of the hippocampus, was only slightly enlarged and thus may not contribute to the cell fate switch. Lef1 expression was significantly upregulated in the lateral, cortical VZ and FoxG1 may function upstream of Wnt signaling. Our results provide new insights into the functions of FoxG1 and the mechanisms of cell fate determination during telencephalic development.

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