The ATPase TER94 Regulates Notch Signaling During Wing Development

Overview

Journal Biol Open

Specialty Biology

Date 2018 Dec 12

PMID 30530809

Citations 6

Authors

Yunlong Li

Tong Liu

Junzheng Zhang

Affiliations

Soon will be listed here.

Abstract

The evolutionarily conserved Notch signaling pathway plays crucial roles in various developmental contexts. Multiple mechanisms are involved in the regulation of Notch pathway activity. Identified through a genetic mosaic screen, we show that the ATPase TER94 acts as a positive regulator of Notch signaling during wing development. Depletion of TER94 causes marginal notches in the adult wing and the reduction of Notch target genes and during wing margin formation. We provide evidence that TER94 is likely required for proper Notch protein localization and activation. Furthermore, we show that knockdown of the TER94 adaptor p47 leads to similar Notch signaling defects. Although the TER94 complex is implicated in various cellular processes, its role in the regulation of Notch pathways was previously uncharacterized. Our study demonstrates that TER94 positively regulates Notch signaling and thus reveals a novel role of TER94 in development.This article has an associated First Person interview with the first author of the paper.

Citing Articles

The AAA-ATPase Ter94 regulates wing size in Drosophila by suppressing the Hippo pathway.

Li M, Ding W, Deng Y, Zhao Y, Liu Q, Zhou Z Commun Biol. 2024; 7(1):533.

PMID: 38710747 PMC: 11074327. DOI: 10.1038/s42003-024-06246-x.

Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions.

Chen Y, Li H, Yi T, Shen J, Zhang J Int J Mol Sci. 2023; 24(18).

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The Ubiquitin Conjugating Enzyme UbcD1 is Required for Notch Signaling Activation During Wing Development.

Zhang F, Chen Y, Shen J, Zhang J Front Genet. 2021; 12:770853.

PMID: 34712275 PMC: 8546230. DOI: 10.3389/fgene.2021.770853.

Reduction of Derlin activity suppresses Notch-dependent tumours in the C. elegans germ line.

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