Cartilage Repair and Inhibition of the Progression of Cartilage Degeneration After Transplantation of Allogeneic Chondrocyte Sheets In a Nontraumatic Early Arthritis Model

Overview

Journal Regen Ther

Date 2018 Dec 8

PMID 30525072

Citations 6

Authors

Naoki Takatori

Masato Sato

Eriko Toyoda

Takumi Takahashi

Eri Okada

Miki Maehara

Masahiko Watanabe

Affiliations

Soon will be listed here.

Abstract

Introduction: Using a rat model of nontraumatic early arthritis induced by intra-articular administration of low-dose monoiodoacetic acid (MIA), we transplanted allogeneic chondrocyte sheets and examined the effects on tissue repair.

Methods: MIA (0.2 mg/50 μl) was injected into the right knee of 20 male Wistar rats. Four weeks later, rats were randomly allocated into three groups: Group A was examined 4 weeks after administration of MIA; Group B, 8 weeks after MIA injection and chondrocyte sheet transplantation, and Group C, 8 weeks after MIA injection but without chondrocyte sheet transplantation. Allogeneic chondrocyte sheets were transplanted into the right knee of Group B rats. Pain was assessed as the weight distribution ratio of the damaged to undamaged limb. The OARSI score was used for histological scoring.

Results: The limb weight distribution ratio indicated significantly less pain in Group B. Histological scoring showed significant differences in cartilage repair and inhibition of the progression of cartilage degeneration between Groups B and C, but not between Groups A and B, or Groups A and C.

Conclusions: These findings suggest that, in this rat model of nontraumatic early arthritis induced by low-dose MIA injection, allogeneic chondrocyte sheet transplantation induces cartilage repair and suppresses cartilage degeneration.

Citing Articles

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Takizawa D, Sato M, Okada E, Takahashi T, Maehara M, Tominaga A J Tissue Eng Regen Med. 2020; 14(9):1296-1306.

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