Protein-Based Salivary Profiles As Novel Biomarkers for Oral Diseases

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2018 Dec 8

PMID 30524521

Citations 29

Authors

Alejandro I Lorenzo-Pouso

Mario Perez-Sayans

Susana B Bravo

Pia Lopez-Jornet

Maria Garcia-Vence

Manuela Alonso-Sampedro

Javier Carballo

Abel Garcia-Garcia

Affiliations

Soon will be listed here.

Abstract

The Global Burden of Oral Diseases affects 3.5 billion people worldwide, representing the number of people affected by the burden of untreated dental caries, severe periodontal disease, and edentulism. Thus, much more efforts in terms of diagnostics and treatments must be provided in the fight of these outcomes. In this sense, recently, the study of saliva as biological matrix has been identified as a new landmark initiative in the search of novel and useful biomarkers to prevent and diagnose these conditions. Specifically, saliva is a rich reservoir of different proteins and peptides and accessible due to recent advances in molecular biology and specially in targeted and unbiased proteomics technologies. Nonetheless, emerging barriers are an obstacle to the study of the salivary proteome in an effective way. This review aims at giving an overall perspective of salivary biomarkers identified in several oral diseases by means of molecular biology approaches.

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