How Do Cells of the Oligodendrocyte Lineage Affect Neuronal Circuits to Influence Motor Function, Memory and Mood?

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2018 Dec 8

PMID 30524235

Citations 36

Authors

Renee E Pepper

Kimberley A Pitman

Carlie L Cullen

Kaylene M Young

Affiliations

Soon will be listed here.

Abstract

Oligodendrocyte progenitor cells (OPCs) are immature cells in the central nervous system (CNS) that can rapidly respond to changes within their environment by modulating their proliferation, motility and differentiation. OPCs differentiate into myelinating oligodendrocytes throughout life, and both cell types have been implicated in maintaining and modulating neuronal function to affect motor performance, cognition and emotional state. However, questions remain about the mechanisms employed by OPCs and oligodendrocytes to regulate circuit function, including whether OPCs can only influence circuits through their generation of new oligodendrocytes, or can play other regulatory roles within the CNS. In this review, we detail the molecular and cellular mechanisms that allow OPCs, newborn oligodendrocytes and pre-existing oligodendrocytes to regulate circuit function and ultimately influence behavioral outcomes.

Citing Articles

Oligodendrocytes use postsynaptic proteins to coordinate myelin formation on axons of distinct neurotransmitter classes.

Carey N, Doll C, Appel B bioRxiv. 2024; .

PMID: 39574762 PMC: 11580840. DOI: 10.1101/2024.10.02.616365.

Human-unique brain cell clusters are associated with learning disorders and human episodic memory activity.

Ma J, Qi R, Wang J, Berto S, Wang G Mol Psychiatry. 2024; 30(1):353-359.

PMID: 39227435 DOI: 10.1038/s41380-024-02722-2.

Unraveling the role of oligodendrocytes and myelin in pain.

Kim W, Angulo M J Neurochem. 2024; 169(1):e16206.

PMID: 39162089 PMC: 11657919. DOI: 10.1111/jnc.16206.

A molecularly defined subpopulation of oligodendrocyte precursor cells controls the generation of myelinating oligodendrocytes during postnatal development.

Moghimyfiroozabad S, Paul M, Bellenger L, Selimi F PLoS Biol. 2024; 22(7):e3002655.

PMID: 38985832 PMC: 11236193. DOI: 10.1371/journal.pbio.3002655.

Investigating the Protective Effects of a Citrus Flavonoid on the Retardation Morphogenesis of the Oligodendroglia-like Cell Line by Rnd2 Knockdown.

Fukatsu S, Miyamoto Y, Oka Y, Ishibashi M, Shirai R, Ishida Y Neurol Int. 2024; 16(1):33-61.

PMID: 38251051 PMC: 10801557. DOI: 10.3390/neurolint16010003.

References

Petit B, Giraudet F, Bechon C, Bardin L, Avan P, Boespflug-Tanguy O . Mice with a deletion of the major central myelin protein exhibit hypersensitivity to noxious thermal stimuli: involvement of central sensitization. Neurobiol Dis. 2014; 65:55-68. DOI: 10.1016/j.nbd.2014.01.005. View

Stedehouder J, Couey J, Brizee D, Hosseini B, Slotman J, Dirven C . Fast-spiking Parvalbumin Interneurons are Frequently Myelinated in the Cerebral Cortex of Mice and Humans. Cereb Cortex. 2017; 27(10):5001-5013. DOI: 10.1093/cercor/bhx203. View

Murcia-Belmonte V, Esteban P, Martinez-Hernandez J, Gruart A, Lujan R, Delgado-Garcia J . Anosmin-1 over-expression regulates oligodendrocyte precursor cell proliferation, migration and myelin sheath thickness. Brain Struct Funct. 2015; 221(3):1365-85. DOI: 10.1007/s00429-014-0977-4. View

Hamada M, Popovic M, Kole M . Loss of Saltation and Presynaptic Action Potential Failure in Demyelinated Axons. Front Cell Neurosci. 2017; 11:45. PMC: 5326753. DOI: 10.3389/fncel.2017.00045. View

Krasnow A, Ford M, Valdivia L, Wilson S, Attwell D . Regulation of developing myelin sheath elongation by oligodendrocyte calcium transients in vivo. Nat Neurosci. 2017; 21(1):24-28. PMC: 6478117. DOI: 10.1038/s41593-017-0031-y. View

Lu Q, Yuk D, Alberta J, Zhu Z, Pawlitzky I, Chan J . Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron. 2000; 25(2):317-29. DOI: 10.1016/s0896-6273(00)80897-1. View

Rosenbluth J . Multiple functions of the paranodal junction of myelinated nerve fibers. J Neurosci Res. 2009; 87(15):3250-8. DOI: 10.1002/jnr.22013. View

Kim J, Renden R, von Gersdorff H . Dysmyelination of auditory afferent axons increases the jitter of action potential timing during high-frequency firing. J Neurosci. 2013; 33(22):9402-7. PMC: 3719047. DOI: 10.1523/JNEUROSCI.3389-12.2013. View

Pringle N, Mudhar H, Collarini E, Richardson W . PDGF receptors in the rat CNS: during late neurogenesis, PDGF alpha-receptor expression appears to be restricted to glial cells of the oligodendrocyte lineage. Development. 1992; 115(2):535-51. DOI: 10.1242/dev.115.2.535. View

10.

Emery B, Agalliu D, Cahoy J, Watkins T, Dugas J, Mulinyawe S . Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell. 2009; 138(1):172-85. PMC: 2757090. DOI: 10.1016/j.cell.2009.04.031. View

11.

Rasband M, Tayler J, Kaga Y, Yang Y, Lappe-Siefke C, Nave K . CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS. Glia. 2005; 50(1):86-90. DOI: 10.1002/glia.20165. View

12.

Stedehouder J, Kushner S . Myelination of parvalbumin interneurons: a parsimonious locus of pathophysiological convergence in schizophrenia. Mol Psychiatry. 2016; 22(1):4-12. PMC: 5414080. DOI: 10.1038/mp.2016.147. View

13.

Shepard R, Page C, Coutellier L . Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: Relevance for sex differences in stress-related disorders. Neuroscience. 2016; 332:1-12. DOI: 10.1016/j.neuroscience.2016.06.038. View

14.

Masahira N, Takebayashi H, Ono K, Watanabe K, Ding L, Furusho M . Olig2-positive progenitors in the embryonic spinal cord give rise not only to motoneurons and oligodendrocytes, but also to a subset of astrocytes and ependymal cells. Dev Biol. 2006; 293(2):358-69. DOI: 10.1016/j.ydbio.2006.02.029. View

15.

Tripathi R, Jackiewicz M, McKenzie I, Kougioumtzidou E, Grist M, Richardson W . Remarkable Stability of Myelinating Oligodendrocytes in Mice. Cell Rep. 2017; 21(2):316-323. PMC: 5643547. DOI: 10.1016/j.celrep.2017.09.050. View

16.

Ono M, Kikusui T, Sasaki N, Ichikawa M, Mori Y, Murakami-Murofushi K . Early weaning induces anxiety and precocious myelination in the anterior part of the basolateral amygdala of male Balb/c mice. Neuroscience. 2008; 156(4):1103-10. DOI: 10.1016/j.neuroscience.2008.07.078. View

17.

Mensch S, Baraban M, Almeida R, Czopka T, Ausborn J, El Manira A . Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo. Nat Neurosci. 2015; 18(5):628-30. PMC: 4427868. DOI: 10.1038/nn.3991. View

18.

McKenzie I, Ohayon D, Li H, de Faria J, Emery B, Tohyama K . Motor skill learning requires active central myelination. Science. 2014; 346(6207):318-22. PMC: 6324726. DOI: 10.1126/science.1254960. View

19.

Uhlhaas P, Pipa G, Lima B, Melloni L, Neuenschwander S, Nikolic D . Neural synchrony in cortical networks: history, concept and current status. Front Integr Neurosci. 2009; 3:17. PMC: 2723047. DOI: 10.3389/neuro.07.017.2009. View

20.

Suzuki A, Stern S, Bozdagi O, Huntley G, Walker R, Magistretti P . Astrocyte-neuron lactate transport is required for long-term memory formation. Cell. 2011; 144(5):810-23. PMC: 3073831. DOI: 10.1016/j.cell.2011.02.018. View