HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth
Overview
Endocrinology
Authors
Affiliations
Alteration of cell energy metabolism represents a major determinant of cancer progression; however, our understanding of oncogenic mechanisms underlying this rewiring remains elusive. In this issue of Cell Metabolism, Kurmi et al. (2018) show that HER2 signaling promotes ABL-mediated phosphorylation of the mitochondrial creatine kinase (MtCK1), providing ATP to support breast tumor growth.
The Metabolic Syndrome, a Human Disease.
Alemany M Int J Mol Sci. 2024; 25(4).
PMID: 38396928 PMC: 10888680. DOI: 10.3390/ijms25042251.
Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression.
Patel R, Ford C, Rodgers L, Rushworth L, Fleming J, Mui E Cancer Res. 2022; 82(14):2565-2575.
PMID: 35675421 PMC: 9381098. DOI: 10.1158/0008-5472.CAN-21-1301.
Yan Z, Yan Z, Liu S, Yin Y, Yang T, Chen Q Front Nutr. 2021; 8:714567.
PMID: 34458310 PMC: 8387576. DOI: 10.3389/fnut.2021.714567.
Beyond mitochondria: Alternative energy-producing pathways from all strata of life.
Auger C, Vinaik R, Appanna V, Jeschke M Metabolism. 2021; 118:154733.
PMID: 33631145 PMC: 8052308. DOI: 10.1016/j.metabol.2021.154733.
Zhang J, Chen X, Chen H, Li R, Xu P, Lv C Pharm Biol. 2020; 58(1):1105-1114.
PMID: 33181025 PMC: 7671710. DOI: 10.1080/13880209.2020.1834590.