Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism

Overview

Journal J Autism Dev Disord

Publisher Springer

Date 2018 Dec 5

PMID 30511125

Citations 15

Authors

Charles Laidi

Jennifer Boisgontier

Amicie de Pierrefeu

Edouard Duchesnay

Sevan Hotier

Marc-Antoine dAlbis

Richard Delorme

Federico Bolognani

Christian Czech

Celine Bouquet

Anouck Amestoy

Julie Petit

Stefan Holiga

Juergen Dukart

Alexandru Gaman

Elie Toledano

Myriam Ly-Le Moal

Isabelle Scheid

Marion Leboyer

Josselin Houenou

Affiliations

Soon will be listed here.

Abstract

Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population.

Citing Articles

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Hao Y, Banker S, Trayvick J, Barkley S, Peters A, Thinakaran A Mol Autism. 2025; 16(1):9.

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Motor predictors of cortical brain development and full-IQ in children born extremely preterm with and without discrete white matter abnormalities.

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Understanding Depression in Autism: The Role of Subjective Perception and Anterior Cingulate Cortex Volume.

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Zheng X, Zhou F, Fu M, Xu L, Wang J, Li J Transl Psychiatry. 2024; 14(1):168.

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