Intravascular Large B-cell Lymphoma Presenting with Diffusely Increased Pulmonary Fluorodeoxyglucose Uptake Without Corresponding CT Abnormality

Overview

Journal Radiol Case Rep

Publisher Elsevier

Specialty Radiology

Date 2018 Dec 5

PMID 30510608

Citations 7

Authors

Jayden Spencer

Reginald Dusing

Wendell Yap

Jacqueline Hill

Carissa Walter

Affiliations

Soon will be listed here.

Abstract

A 60-year-old male presented with complaints of dyspnea, intermittent fever, and 40 pounds of weight loss over the previous 9 months and was admitted for acute hypoxemic respiratory failure. Labs demonstrated elevated inflammatory markers, mild anemia, and thrombocytopenia. Fluorodeoxyglucose-positron emission tomography scan demonstrated diffusely increased pulmonary fluorodeoxyglucose uptake without corresponding abnormality on CT images. Excisional lung biopsy demonstrated intravascular large B-cell lymphoma (IV-LBCL). Presentation, imaging findings, and diagnosis of IV-LBCL will be discussed, as well as differential considerations for pulmonary involvement by IV-LBCL.

Citing Articles

CT-Imaging Manifestations and Diagnostic Insights in Pulmonary Intravascular Large B-Cell Lymphoma: A Case Series and Literature Review.

Gou X, Zhang Y, Li Y, Hu L, Cheng J, Hong N Cancer Rep (Hoboken). 2025; 8(3):e70159.

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Primary pulmonary intravascular large B‑cell lymphoma: Indications from cytomorphology findings through CT‑guided puncture: A case report.

Jiang W, Li M, Zhang C, Xing X Oncol Lett. 2024; 29(1):46.

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Case Report: Intravascular Large B-Cell Lymphoma: A Clinicopathologic Study of Four Cases With Review of Additional 331 Cases in the Literature.

Han Y, Li Q, Wang D, Peng L, Huang T, Ou C Front Oncol. 2022; 12:883141.

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References

Domizio P, Hall P, Cotter F, Amiel S, Tucker J, Besser G . Angiotropic large cell lymphoma (ALCL): morphological, immunohistochemical and genotypic studies with analysis of previous reports. Hematol Oncol. 1989; 7(3):195-206. DOI: 10.1002/hon.2900070303. View

Ponzoni M, Ferreri A, Campo E, Facchetti F, Mazzucchelli L, Yoshino T . Definition, diagnosis, and management of intravascular large B-cell lymphoma: proposals and perspectives from an international consensus meeting. J Clin Oncol. 2007; 25(21):3168-73. DOI: 10.1200/JCO.2006.08.2313. View

Asada N, Odawara J, Kimura S, Aoki T, Yamakura M, Takeuchi M . Use of random skin biopsy for diagnosis of intravascular large B-cell lymphoma. Mayo Clin Proc. 2007; 82(12):1525-7. DOI: 10.1016/s0025-6196(11)61097-5. View

Zuckerman D, Seliem R, Hochberg E . Intravascular lymphoma: the oncologist's "great imitator". Oncologist. 2006; 11(5):496-502. DOI: 10.1634/theoncologist.11-5-496. View

Ferreri A, Campo E, Seymour J, Willemze R, Ilariucci F, Ambrosetti A . Intravascular lymphoma: clinical presentation, natural history, management and prognostic factors in a series of 38 cases, with special emphasis on the 'cutaneous variant'. Br J Haematol. 2004; 127(2):173-83. DOI: 10.1111/j.1365-2141.2004.05177.x. View

Aouba A, Diop S, Saadoun D, Trebbia G, Vilde F, Patri B . Severe pulmonary arterial hypertension as initial manifestation of intravascular lymphoma: case report. Am J Hematol. 2005; 79(1):46-9. DOI: 10.1002/ajh.20300. View

Shimada K, Kinoshita T, Naoe T, Nakamura S . Presentation and management of intravascular large B-cell lymphoma. Lancet Oncol. 2009; 10(9):895-902. DOI: 10.1016/S1470-2045(09)70140-8. View

Ponzoni M, Arrigoni G, Gould V, Del Curto B, Maggioni M, Scapinello A . Lack of CD 29 (beta1 integrin) and CD 54 (ICAM-1) adhesion molecules in intravascular lymphomatosis. Hum Pathol. 2000; 31(2):220-6. DOI: 10.1016/s0046-8177(00)80223-3. View

von Rohr L, Klaeser B, Joerger M, Kluckert T, Cerny T, Gillessen S . Increased pulmonary FDG uptake in bleomycin-associated pneumonitis. Onkologie. 2007; 30(6):320-3. DOI: 10.1159/000101517. View

10.

Rodrigues R, Miller P, Bozza F, Marchiori E, Zimmerman G, Hoffman J . FDG-PET in patients at risk for acute respiratory distress syndrome: a preliminary report. Intensive Care Med. 2008; 34(12):2273-8. DOI: 10.1007/s00134-008-1220-7. View

11.

Baumann T, Hurwitz N, Probst A, Herrmann R, Steck A . Diagnosis and treatment of intravascular lymphomatosis. Arch Neurol. 2000; 57(3):374-7. DOI: 10.1001/archneur.57.3.374. View

12.

Kotake T, Kosugi S, Takimoto T, Nakata S, Shiga J, Nagate Y . Intravascular large B-cell lymphoma presenting pulmonary arterial hypertension as an initial manifestation. Intern Med. 2010; 49(1):51-4. DOI: 10.2169/internalmedicine.49.2774. View

13.

Miura Y, Tsudo M . Fluorodeoxyglucose-PET/CT for diagnosis of intravascular large B-cell lymphoma. Mayo Clin Proc. 2010; 85(8):e56-7. PMC: 2912750. DOI: 10.4065/mcp.2009.0716. View

14.

Yamane T, Daimaru O, Ito S, Nagata T, Yoshiya K, Fukaya N . Drug-induced pneumonitis detected earlier by 18F-FDG-PET than by high-resolution CT: a case report with non-Hodgkin's lymphoma. Ann Nucl Med. 2008; 22(8):719-22. DOI: 10.1007/s12149-008-0183-7. View

15.

Kitanaka A, Kubota Y, Imataki O, Ohnishi H, Fukumoto T, Kurokohchi K . Intravascular large B-cell lymphoma with FDG accumulation in the lung lacking CT/(67)gallium scintigraphy abnormality. Hematol Oncol. 2008; 27(1):46-9. DOI: 10.1002/hon.876. View

16.

Souza C, Quan K, Seely J, Kravcik S, Burns B . Pulmonary intravascular lymphoma. J Thorac Imaging. 2009; 24(3):231-3. DOI: 10.1097/RTI.0b013e31819724d9. View

17.

Martusewicz-Boros M, Wiatr E, Radzikowska E, Roszkowski-Sliz K, Langfort R . Pulmonary intravascular large B-cell lymphoma as a cause of severe hypoxemia. J Clin Oncol. 2007; 25(15):2137-9. DOI: 10.1200/JCO.2007.10.7201. View

18.

Demirer T, Dail D, Aboulafia D . Four varied cases of intravascular lymphomatosis and a literature review. Cancer. 1994; 73(6):1738-45. DOI: 10.1002/1097-0142(19940315)73:6<1738::aid-cncr2820730631>3.0.co;2-u. View

19.

Niida T, Isoda K, Miyazaki K, Kanoh S, Kobayashi H, Kobayashi A . Pulmonary intravascular lymphoma diagnosed by 18-fluorodeoxyglucose positron emission tomography-guided transbronchial lung biopsy in a man with long-term survival: a case report. J Med Case Rep. 2011; 5:295. PMC: 3152526. DOI: 10.1186/1752-1947-5-295. View

20.

Yamashita H, Suzuki A, Takahashi Y, Kubota K, Kano T, Mimori A . Intravascular large B-cell lymphoma with diffuse FDG uptake in the lung by 18FDG-PET/CT without chest CT findings. Ann Nucl Med. 2012; 26(6):515-21. PMC: 7102326. DOI: 10.1007/s12149-012-0600-9. View