Timing of Upper Gastrointestinal Endoscopy Does Not Influence Short-term Outcomes in Patients with Acute Variceal Bleeding

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2018 Dec 5

PMID 30510377

Citations 6

Authors

Jeong-Ju Yoo

Young Chang

Eun Ju Cho

Ji Eun Moon

Sang Gyune Kim

Young Seok Kim

Yun Bin Lee

Jeong-Hoon Lee

Su Jong Yu

Yoon Jun Kim

Jung-Hwan Yoon

Affiliations

Soon will be listed here.

Abstract

Aim: To examine the association between the timing of endoscopy and the short-term outcomes of acute variceal bleeding in cirrhotic patients.

Methods: This retrospective study included 274 consecutive patients admitted with acute esophageal variceal bleeding of two tertiary hospitals in Korea. We adjusted confounding factors using the Cox proportional hazards model and the inverse probability weighting (IPW) method. The primary outcome was the mortality of patients within 6 wk.

Results: A total of 173 patients received urgent endoscopy (., ≤ 12 h after admission), and 101 patients received non-urgent endoscopy (> 12 h after admission). The 6-wk mortality rate was 22.5% in the urgent endoscopy group and 29.7% in the non-urgent endoscopy group, and there was no significant difference between the two groups before ( = 0.266) and after IPW ( = 0.639). The length of hospital stay was statistically different between the urgent group and non-urgent group ( = 0.033); however, there was no significant difference in the in-hospital mortality rate between the two groups (8.1% 7.9%, = 0.960). In multivariate analyses, timing of endoscopy was not associated with 6-wk mortality (hazard ratio, 1.297; 95% confidence interval, 0.806-2.089; = 0.284).

Conclusion: In cirrhotic patients with acute variceal bleeding, the timing of endoscopy may be independent of short-term mortality.

Citing Articles

Timing of endoscopy in cirrhotic patients with acute variceal bleeding: protocol of a multicenter randomized controlled trial.

Qi X, Li Y, Li B, Luo X, Liu X, Zhang C Therap Adv Gastroenterol. 2024; 17:17562848241295452.

PMID: 39539489 PMC: 11558738. DOI: 10.1177/17562848241295452.

Timing of endoscopy in patients with cirrhosis and acute variceal bleeding: a single-center retrospective study.

Peng M, Bai Z, Zou D, Xu S, Wang C, Basaranoglu M BMC Gastroenterol. 2023; 23(1):219.

PMID: 37365510 PMC: 10291747. DOI: 10.1186/s12876-023-02766-8.

Timing of endoscopic intervention in patients with cirrhosis with acute variceal haemorrhage (TEACH trial): protocol for a randomised clinical trial (RCT).

Yang Z, Xuan J, Yang F, Qi Y, Yang M, Xu H BMJ Open. 2023; 12(9):e060290.

PMID: 36691157 PMC: 9442483. DOI: 10.1136/bmjopen-2021-060290.

Analysis of the timing of endoscopic treatment for esophagogastric variceal bleeding in cirrhosis.

Wu K, Fu Y, Guo Z, Zhou X Front Med (Lausanne). 2022; 9:1036491.

PMID: 36530902 PMC: 9754091. DOI: 10.3389/fmed.2022.1036491.

The influences of timing of urgent endoscopy in patients with acute variceal bleeding: a cohort study.

Yan X, Leng Z, Xu Q, Zhang Z, Xu M, Li J BMC Gastroenterol. 2022; 22(1):506.

PMID: 36482309 PMC: 9733049. DOI: 10.1186/s12876-022-02595-1.

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