The Genetic Basis of Disease

Overview

Journal Essays Biochem

Specialty Biochemistry

Date 2018 Dec 5

PMID 30509934

Citations 86

Authors

Maria Jackson

Leah Marks

Gerhard H W May

Joanna B Wilson

Affiliations

Soon will be listed here.

Abstract

Genetics plays a role, to a greater or lesser extent, in all diseases. Variations in our DNA and differences in how that DNA functions (alone or in combinations), alongside the environment (which encompasses lifestyle), contribute to disease processes. This review explores the genetic basis of human disease, including single gene disorders, chromosomal imbalances, epigenetics, cancer and complex disorders, and considers how our understanding and technological advances can be applied to provision of appropriate diagnosis, management and therapy for patients.

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