Lack of Association Between Genetic Polymorphisms in IGF1 and IGFBP3 with Twin Births in a Brazilian Population (Cândido Godói, Rio Grande Do Sul)

Overview

Journal Genet Mol Biol

Specialty Genetics

Date 2018 Dec 4

PMID 30508002

Citations 2

Authors

Mariana de Oliveira-Klein

Augusto Cesar Cardoso-Dos-Santos

Alice Tagliani-Ribeiro

Nelson Rosa Fagundes

Ursula Matte

Lavinia Schuler-Faccini

Affiliations

Soon will be listed here.

Abstract

Insulin-like growth factor (IGF-1) is an important peptide hormone involved in the reproduction and fetal development of mammals, and it is suggested that it may influence the human twinning rate. This study aimed to test such possible association, investigating the genetic polymorphisms IGF1 (CA)n and IGFBP3 rs2854744 in the population from Candido Godoi (CG), a small city located in the South of Brazil that has a high prevalence of twin births. A case-control study was performed comprising a total of 39 cases (representing about 40% of the mothers of twins who were born in CG after 1995) and 214 controls (mothers of non-twin children), 97 of whom were living in CG while 117 were living in Porto Alegre. DNA was extracted from blood leucocytes and genotyping was performed. According to the statistical analyses, there was no significant difference in the frequencies of both studied genetic polymorphisms when comparing case group with control group. Thus, our results pointed to a lack of association between IGF1 (CA)n and IGFBP3 rs2854744 polymorphisms and twin births in CG, but further investigations in other populations with different characteristics must be performed to confirm the role of IGF-I in human twinning.

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