Potassium 2-(1-hydroxypentyl)-benzoate Improves Depressive-like Behaviors in Rat Model

Overview

Journal Acta Pharm Sin B

Publisher Elsevier

Specialty Pharmacology

Date 2018 Dec 4

PMID 30505657

Citations 10

Authors

Hao Ma

Weiping Wang

Shaofeng Xu

Ling Wang

Xiaoliang Wang

Affiliations

Soon will be listed here.

Abstract

Potassium 2-(1-hydroxypentyl)-benzoate (PHPB) is a novel drug candidate for acute ischemic stroke. PHPB has been also shown to be beneficial for some neurodegenerative diseases. In this study, we demonstrated that PHPB improved depressive-like behaviors induced by chronic unpredictable mild stress (CUMS) in rats. Male SD rats were subjected to the stress for five weeks. PHPB (30 and 100 mg/kg) or fluoxetine (FLX 10 mg/kg, as positive control) was administered orally from the third week in CUMS procedure. The behavioral tests were applied and then the biochemical studies were carried out. PHPB or FLX treatment rescued the behavioral deficiency in CUMS-exposed rats. Meanwhile, PHPB normalized the enhanced level of serum corticosterone, improved hippocampal and serum BDNF levels, as well as p-CREB level in hippocampus. In addition, PHPB could reverse the reduced level of extracellular 5-HT and its metabolite 5-HIAA in prefrontal cortex (PFC) of depressed rats. In summary, our results showed that PHPB improved depression-like behaviors in CUMS-exposed rats. The mechanisms might relate to the reverse of neurotrophic disturbance in the brain, reducing excessive HPA axis response and facilitating the release of 5-HT.

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References

Campos A, Barros A, Albuquerque F, Leal L, Rao V . Acute effects of guarana (Paullinia cupana Mart.) on mouse behaviour in forced swimming and open field tests. Phytother Res. 2005; 19(5):441-3. DOI: 10.1002/ptr.1471. View

Yang L, Li J, Xu S, Cai J, Lei H, Liu D . L-3-n-butylphthalide Promotes Neurogenesis and Neuroplasticity in Cerebral Ischemic Rats. CNS Neurosci Ther. 2015; 21(9):733-41. PMC: 6493029. DOI: 10.1111/cns.12438. View

Maric N, Adzic M . Pharmacological modulation of HPA axis in depression - new avenues for potential therapeutic benefits. Psychiatr Danub. 2013; 25(3):299-305. View

Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C . Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry. 2003; 54(1):70-5. DOI: 10.1016/s0006-3223(03)00181-1. View

Nagayasu K, Kitaichi M, Nishitani N, Asaoka N, Shirakawa H, Nakagawa T . Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: high potency of milnacipran in the augmentation of serotonin release. Int J Neuropsychopharmacol. 2013; 16(10):2295-306. DOI: 10.1017/S1461145713000771. View

Werner F, Covenas R . Classical neurotransmitters and neuropeptides involved in major depression: a review. Int J Neurosci. 2010; 120(7):455-70. DOI: 10.3109/00207454.2010.483651. View

Rosen R, Marin H . Prevalence of antidepressant-associated erectile dysfunction. J Clin Psychiatry. 2003; 64 Suppl 10:5-10. View

Sun J, Liu Y, Yuan Y, Li J, Chen N . Gap junction dysfunction in the prefrontal cortex induces depressive-like behaviors in rats. Neuropsychopharmacology. 2011; 37(5):1305-20. PMC: 3306892. DOI: 10.1038/npp.2011.319. View

Zhao W, Xu S, Peng Y, Ji X, Cao D, Li J . Potassium 2-(1-hydroxypentyl)-benzoate improves learning and memory deficits in chronic cerebral hypoperfused rats. Neurosci Lett. 2013; 541:155-60. DOI: 10.1016/j.neulet.2013.01.053. View

10.

Xu Y, Wang Z, You W, Zhang X, Li S, Barish P . Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system. Eur Neuropsychopharmacol. 2010; 20(6):405-13. DOI: 10.1016/j.euroneuro.2010.02.013. View

11.

Masi G, Brovedani P . The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression. CNS Drugs. 2011; 25(11):913-31. DOI: 10.2165/11595900-000000000-00000. View

12.

Li M, Fu Q, Li Y, Li S, Xue J, Ma S . Emodin opposes chronic unpredictable mild stress induced depressive-like behavior in mice by upregulating the levels of hippocampal glucocorticoid receptor and brain-derived neurotrophic factor. Fitoterapia. 2014; 98:1-10. DOI: 10.1016/j.fitote.2014.06.007. View

13.

Porsolt R, Anton G, Blavet N, JALFRE M . Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol. 1978; 47(4):379-91. DOI: 10.1016/0014-2999(78)90118-8. View

14.

Tafet G, Nemeroff C . The Links Between Stress and Depression: Psychoneuroendocrinological, Genetic, and Environmental Interactions. J Neuropsychiatry Clin Neurosci. 2015; 28(2):77-88. DOI: 10.1176/appi.neuropsych.15030053. View

15.

Bao A, Meynen G, Swaab D . The stress system in depression and neurodegeneration: focus on the human hypothalamus. Brain Res Rev. 2007; 57(2):531-53. DOI: 10.1016/j.brainresrev.2007.04.005. View

16.

Taliaz D, Stall N, Dar D, Zangen A . Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry. 2009; 15(1):80-92. PMC: 2834321. DOI: 10.1038/mp.2009.67. View

17.

Gold P, Machado-Vieira R, Pavlatou M . Clinical and biochemical manifestations of depression: relation to the neurobiology of stress. Neural Plast. 2015; 2015:581976. PMC: 4387963. DOI: 10.1155/2015/581976. View

18.

Luo J, Zhang L, Ning N, Jiang H, Yu S . Neotrofin reverses the effects of chronic unpredictable mild stress on behavior via regulating BDNF, PSD-95 and synaptophysin expression in rat. Behav Brain Res. 2013; 253:48-53. DOI: 10.1016/j.bbr.2013.07.014. View

19.

Liu D, Xie K, Yang X, Gu J, Ge L, Wang X . Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats. Behav Brain Res. 2014; 264:9-16. DOI: 10.1016/j.bbr.2014.01.039. View

20.

Czeh B, Lucassen P . What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated?. Eur Arch Psychiatry Clin Neurosci. 2007; 257(5):250-60. DOI: 10.1007/s00406-007-0728-0. View