Compass Mapping, Double Potentials, Activation Patterns Can Identify and Track Rotational Activity Sites in the Left Atrium of Humans with Persistent Atrial Fibrillation

Overview

Journal J Atr Fibrillation

Date 2018 Dec 4

PMID 30505380

Citations 1

Authors

Donald S Rubenstein

Hang Yin

Sana A Azami

Affiliations

Soon will be listed here.

Abstract

Background: Rotational circuits that occur between bipolar electrodes exhibit double potentials (DPs). It had been previously surmised that rotors could not be electrically tracked directly.

Purpose: Our purpose was twofold; first, to show that the use of compass mapping, one can regionally identify rotational activity; and second, to show that by combining simultaneous compass map recordings, standard narrow-adjacent bipolar, and unipolar recordings, that specific signature recording patterns emerge that allow one to identify the accurate time, location, and path of a rotational mechanism.

Methods: This was an observational study in 20 patients with persistent atrial fibrillation in which the electrode configuration of a circular mapping catheter was changed to wide cross-circle electrode pairing (compass mapping). DPs were recorded and analyzed from 12 left atrial (LA) sites and identified electrical wavefront patterns and direction. A substudy analyzed transitions patterns with simultaneous narrow-adjacent bipolar and unipolar recordings.

Results: Four wavefront patterns were identified: DPs, peripheral waves (PWs), distal peripheral waves and fibrillatory activity. DP wavefront patterns exhibited significantly shorter cycle lengths than PWs in 8 of 12 LA sites. Patients had 2.9± 2.1 regions that exhibited DPs. DPs of varying duration were found, few (25%) were of stable duration and location. Detailed electrical examination at the transition between a PW to a DP identified a highly consistent pattern of simultaneous reversal of activation sequence, a special form of Doppler effect for spiral waves as a rotor passes between 2 electrodes, and a ½ cycle drop-off of activation signals along the line of electrodes.

Conclusion: DP recordings in compass mode can provide a regional assessment for the existence of rotational activity. Simultaneous DP recordings in compass mode, narrow-adjacent bipolar, and unipolar recording provide an accurate assessment of the time, location, and path that a rotational mechanism breaches a perimeter of electrodes. Accurate time, location and path of perimeter breaches can be used to electrically track rotational mechanisms during atrial fibrillation.

Citing Articles

The spiral wave frequency effect in atrial fibrillation.

Rubenstein D, Rubenstein M, Cummins J, Belinskiy B, Cox C Biophys J. 2024; 123(7):782-798.

PMID: 38341756 PMC: 10995432. DOI: 10.1016/j.bpj.2024.02.004.

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