Evaluation of Antioxidant and Anticancer Activities of Chemical Constituents of the Root Extracts

Overview

Journal Saudi J Biol Sci

Specialty Biology

Date 2018 Dec 4

PMID 30505186

Citations 11

Authors

Abdullah Alaklabi

Ibrahim A Arif

Anis Ahamed

Radhakrishnan Surendra Kumar

Akbar Idhayadhulla

Affiliations

Soon will be listed here.

Abstract

Evaluation of antioxidant and anticancer activities were screened by various root extracts. Four solvents (ethyl acetate, methanol, ethanol, and water) extracts were investigated for their total flavonoids, phenol contents and their antioxidant activity of DPPH (2,2-diphenyl-1-picrylhydrazyl), NO (nitric oxide), HO (hydrogen peroxide), ABTS 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonicacid)diammonium assays, FRAP (ferric reducing ability of plasma) assays and anticancer activity. The total phenolic and flavonoid content of extracts were determined by using FC (Folin-Ciocalteu) and AlCl colorimetric assay method. Total flavonoid content in these plants ranged from 24.7 to 72.1 mg g and amount of free phenolic compounds was between 11.2 and 67.1 mg g extract. The all extracts have significant levels of phenolics and flavonoids content. Anticancer activity was screened for MCF-7 breast cancer cell line. Ethanol extract shows significant of antioxidant activity and water extract shows significant of anticancer activity compared with standard (BHT) butylated hydroxy toluene. These ethanol and water extracts could be considered as a natural source for using antioxidant, and anticancer agents compared to commercial available synthetic drugs.

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