A Low GLP-1 Response Among Patients Treated for Acute Organophosphate and Carbamate Poisoning: a Comparative Cross-sectional Study from an Agrarian Region of Sri Lanka

Overview

Journal Environ Sci Pollut Res Int

Publisher Springer

Specialties Environmental Health
Toxicology

Date 2018 Dec 1

PMID 30499084

Citations 4

Authors

Devarajan Rathish

Indika Senavirathna

Channa Jayasumana

Suneth Agampodi

Sisira Siribaddana

Affiliations

Soon will be listed here.

Abstract

Higher incidence of diabetes along with increased use of pesticides is seen in Southeast Asia. Recent hypothesis postulated a link between acetylcholinesterase inhibitor insecticides and type 2 diabetes through the GLP-1 pathway. This study compares the GLP-1 response between groups with low and high red blood cell acetylcholinesterase (RBC-AChE) activity. A comparative cross-sectional study was conducted amongst patients who were within 3 months after an acute organophosphate or carbamate poisoning (acute group) and amongst vegetable farmers with low (chronic group) and high (control group) RBC-AChE activity. Acute (366 mU/μM Hb) and chronic (361 mU/μM Hb) groups had significantly lower RBC-AChE activity in comparison to the control (471 mU/μM Hb) group (P < 0.0001). Only the acute group, which has had atropine therapy, showed a significantly lower 120 min value in comparison to the control group (P = 0.0028). Also, the acute group had significantly low late (P = 0.0287) and total (P = 0.0358) responses of GLP-1 in comparison to the control group. The findings of the study allude towards attenuation of GLP-1 response amongst patients after acute organophosphate and carbamate poisoning. The possibility of an atropine-mediated attenuation of GLP-1 response was discussed.

Citing Articles

Selected Liver Markers in Predicting the Severity of Organophosphate and Carbamate Poisoning.

Senarathne R, Hettiaratchi U, Athiththan L, Peiris H, Sarathchandra C, Senanayake H J Environ Public Health. 2022; 2022:7826396.

PMID: 35755887 PMC: 9232371. DOI: 10.1155/2022/7826396.

Organophosphate pesticides and new-onset diabetes mellitus: From molecular mechanisms to a possible therapeutic perspective.

Chung Y, Hou Y, Wang I, Lu K, Yen T World J Diabetes. 2021; 12(11):1818-1831.

PMID: 34888010 PMC: 8613664. DOI: 10.4239/wjd.v12.i11.1818.

In vivo, ex vivo and in vitro evidence for atropine-mediated attenuation of glucagon-like peptide-1 secretion: findings from a systematic review.

Rathish D, Agampodi S, Jayasumana C Environ Sci Pollut Res Int. 2019; 26(29):29597-29605.

PMID: 31446595 DOI: 10.1007/s11356-019-06227-2.

Comparison of biochemical parameters among DPP4 inhibitor users and other oral hypoglycaemic drug users: a cross-sectional study from Anuradhapura, Sri Lanka.

Rathish D, Jayasumana C, Agampodi S J Health Popul Nutr. 2019; 38(1):3.

PMID: 30674350 PMC: 6343272. DOI: 10.1186/s41043-019-0160-x.

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