Alterations in Bone Turnover Markers in Patients with Noncardio-embolic Ischemic Stroke

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Nov 30

PMID 30496210

Citations 8

Authors

K Mathold

P Wanby

L Brudin

S P Von

M Carlsson

Affiliations

Soon will be listed here.

Abstract

Background: The major cause of ischemic stroke is unstable or thrombogenic atherosclerotic plaques. Vascular calcification, a process that appears crucial for plaque stability, shares common features with bone formation. Many bone turnover proteins exhibit metabolic properties, but the evidence is conflicting regarding their possible involvement in vascular disease. Antibodies against sclerostin and dickkopf-1 are currently being evaluated as potential therapy for treating bone disorders. It is important to carefully assess the cardiovascular and metabolic effects of these proteins. The aim of the present study was to explore serum levels of bone turnover markers in patients with acute noncardio-embolic ischemic stroke in comparison with healthy controls.

Methods: In a cross-sectional study, we compared 48 patients aged ≥75 years with noncardio-embolic ischemic stroke and 46 healthy controls. Serum levels of dickkopf-1, sclerostin, osteoprotegerin, osteopontin and osteocalcin were determined by Luminex technique.

Results: We found clearly increased serum levels of osteoprotegerin, sclerostin, dickkopf-1 and osteopontin in patients with stroke compared with healthy controls. No difference was seen in serum levels of osteocalcin between the two groups.

Conclusion: Our findings strengthen the hypothesis of bone turnover markers being involved in vascular disease. Whether these proteins can be used as candidate markers for increased stroke risk or prognostic biomarkers remains to be further elucidated.

Citing Articles

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PMID: 39227406 DOI: 10.1007/s10143-024-02755-9.

The Relationship between Sclerostin and Kidney Transplantation Mineral Bone Disorders: A Molecule of Controversies.

Afsar B, Afsar R, Caliskan Y, Lentine K Calcif Tissue Int. 2024; 115(4):339-361.

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Prognostic effect of osteoprotegerin in patients with ischemic stroke: A systematic review and meta-analysis.

Pang L, Lin H, Wei X, Wei W, Lan Y PLoS One. 2024; 19(5):e0303832.

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Albumin-to-alkaline phosphatase ratio may be a better predictor of survival than sclerostin, dickkopf-1, osteopontin, osteoprotegerin and osteocalcin.

Mathold K, Nobin R, Brudin L, Carlsson M, Wanby P Heliyon. 2024; 10(8):e29639.

PMID: 38644839 PMC: 11031828. DOI: 10.1016/j.heliyon.2024.e29639.

Exploring the Role of Sclerostin as a Biomarker of Cardiovascular Disease and Mortality: A Scoping Review.

Sanabria-de la Torre R, Gonzalez-Salvatierra S, Garcia-Fontana C, Andujar-Vera F, Garcia-Fontana B, Munoz-Torres M Int J Environ Res Public Health. 2022; 19(23).

PMID: 36498053 PMC: 9739125. DOI: 10.3390/ijerph192315981.

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