Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease

Overview

Journal Children (Basel)

Specialty Health Services

Date 2018 Nov 30

PMID 30486462

Citations 40

Authors

Anica I Mohammadkhah

Eoin B Simpson

Stephanie G Patterson

Jane F Ferguson

Affiliations

Soon will be listed here.

Abstract

Emerging evidence suggests that microbiome composition and function is associated with development of obesity and metabolic disease. Microbial colonization expands rapidly following birth, and microbiome composition is particularly variable during infancy. Factors that influence the formation of the gut microbiome during infancy and childhood may have a significant impact on development of obesity and metabolic dysfunction, with life-long consequences. In this review, we examine the determinants of gut microbiome composition during infancy and childhood, and evaluate the potential impact on obesity and cardiometabolic risk.

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