The Ambivalent Function of YAP in Apoptosis and Cancer

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Nov 30

PMID 30486435

Citations 28

Authors

Xianbin Zhang

Ahmed Abdelrahman

Brigitte Vollmar

Dietmar Zechner

Affiliations

Soon will be listed here.

Abstract

Yes-associated protein, a core regulator of the Hippo-YAP signaling pathway, plays a vital role in inhibiting apoptosis. Thus, several studies and reviews suggest that yes-associated protein is a good target for treating cancer. Unfortunately, more and more evidence demonstrates that this protein is also an essential contributor of p73-mediated apoptosis. This questions the concept that yes-associated protein is always a good target for developing novel anti-cancer drugs. Thus, the aim of this review was to evaluate the clinical relevance of yes-associated protein for cancer pathophysiology. This review also summarized the molecules, processes and drugs, which regulate Hippo-YAP signaling and discusses their effect on apoptosis. In addition, issues are defined, which should be addressed in the future in order to provide a solid basis for targeting the Hippo-YAP signaling pathway in clinical trials.

Citing Articles

The Role of Yes-Associated Protein in Inflammatory Diseases and Cancer.

Zhong B, Du J, Liu F, Sun S MedComm (2020). 2025; 6(3):e70128.

PMID: 40066231 PMC: 11892025. DOI: 10.1002/mco2.70128.

Molecular mechanisms of Hippo pathway in tumorigenesis: therapeutic implications.

Saadh M, Ahmed H, Kareem R, Kumar Bishoyi A, Roopashree R, Shit D Mol Biol Rep. 2025; 52(1):267.

PMID: 40014178 DOI: 10.1007/s11033-025-10372-y.

Extrinsic induction of apoptosis and tumor suppression via the p53-Reprimo-Hippo-YAP/TAZ-p73 pathway.

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The Hippo Signaling Pathway, Reactive Oxygen Species Production, and Oxidative Stress: A Two-Way Traffic Regulation.

Amanda B, Pragasta R, Cakrasana H, Mustika A, Faizah Z, Oceandy D Cells. 2024; 13(22).

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