Recessive Mechanisms of Malignancy
Overview
Authors
Affiliations
It is increasingly recognised that recessive mutations play an important role in the pathogenesis of many forms of malignancy. Some of the affected loci may prove to be recessively-activated proto-oncogenes, but others are now known to be tumorigenic solely by virtue of their loss or inactivation and therefore form a distinct and novel family of tumour genes. Preliminary evidence suggests that such genes are likely to be functionally heterogeneous and to encode molecules involved in the inhibition of cellular proliferation and/or the induction of differentiation. Their further study is likely to illuminate fundamental mechanisms of normal cellular growth and differentiation as well as having important implications for the pathogenesis and management of cancer.
A rationalized definition of general tumor suppressor microRNAs excludes miR-34a.
Mockly S, Houbron E, Seitz H Nucleic Acids Res. 2022; 50(8):4703-4712.
PMID: 35474387 PMC: 9071449. DOI: 10.1093/nar/gkac277.
Mann J, Dodd H, Draper G, Waterhouse J, Birch J, Cartwright R Br J Cancer. 1993; 68(2):357-63.
PMID: 8347491 PMC: 1968541. DOI: 10.1038/bjc.1993.340.
Watatani M, Nagayama K, Imanishi Y, Kurooka K, Wada T, Inui H Breast Cancer Res Treat. 1993; 28(3):231-9.
PMID: 7912561 DOI: 10.1007/BF00666584.
Mutator phenotype of Werner syndrome is characterized by extensive deletions.
Fukuchi K, Martin G, Monnat Jr R Proc Natl Acad Sci U S A. 1989; 86(15):5893-7.
PMID: 2762303 PMC: 297737. DOI: 10.1073/pnas.86.15.5893.
Kumazawa H, Takagi H, Sudo K, Nakamura W, Hosoda S Virchows Arch A Pathol Anat Histopathol. 1989; 416(2):141-51.
PMID: 2512742 DOI: 10.1007/BF01606319.