Iron and Virulence in : All We Know So Far

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2018 Nov 29

PMID 30483485

Citations 17

Authors

V Kalidasan

Narcisse Joseph

Suresh Kumar

Rukman Awang Hamat

Vasantha Kumari Neela

Affiliations

Soon will be listed here.

Abstract

is a multi-drug-resistant global opportunistic nosocomial pathogen, which possesses a huge number of virulence factors and antibiotics resistance characteristics. Iron has a crucial contribution toward growth and development, cell growth and proliferation, and pathogenicity. The bacterium found to acquire iron for its cellular process through the expression of two iron acquisition systems. Two distinct pathways for iron acquisition are encoded by the genome-a siderophore-and heme-mediated iron uptake system. The operon directs the production of the enterobactin siderophore of catecholate in nature, while heme uptake relies on and potentially operon. Fur and sigma factors are regulators of under iron-limited condition. Iron potentially act as a signal which plays an important role in biofilm formation, extracellular polymeric substances (EPS), extracellular enzymes production, oxidative stress response, diffusible signal factor (DSF) and siderophore production in . This review summarizes the current knowledge of iron acquisition in and the critical role of iron in relation to its pathogenicity.

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