Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis

Overview

Journal Front Cell Infect Microbiol

Specialties Cell Biology
Infectious Diseases
Microbiology

Date 2018 Nov 29

PMID 30483481

Citations 31

Authors

Micely DEl-Rei Hermida

Caroline Vilas Boas de Melo

Isadora Dos Santos Lima

Geraldo Gileno de Sa Oliveira

Washington L C Dos-Santos

Affiliations

Soon will be listed here.

Abstract

The spleen is a secondary lymphoid organ responsible for immune surveillance against blood-circulating pathogens. Absence of the spleen is associated with increased susceptibility to systemic spread and fatal infection by different pathogens. Severe forms of visceral leishmaniasis are associated with disorganization of spleen compartments where cell interactions essential for splenic immunological function take place. White pulp atrophies, secondary lymphoid follicles and marginal zones vanish, and the boundaries separating white and red pulp blur. Leukocyte populations are reduced or disappear or are replaced by plasma cells. In this paper, we review the published data on spleen disorganization in severe forms of visceral leishmaniasis and propose a histological classification to help the exchange of information among research groups.

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