Large Volume Electron Microscopy and Neural Microcircuit Analysis

Overview

Journal Front Neural Circuits

Date 2018 Nov 29

PMID 30483066

Citations 34

Authors

Yoshiyuki Kubota

Jaerin Sohn

Yasuo Kawaguchi

Affiliations

Soon will be listed here.

Abstract

One recent technical innovation in neuroscience is microcircuit analysis using three-dimensional reconstructions of neural elements with a large volume Electron microscopy (EM) data set. Large-scale data sets are acquired with newly-developed electron microscope systems such as automated tape-collecting ultramicrotomy (ATUM) with scanning EM (SEM), serial block-face EM (SBEM) and focused ion beam-SEM (FIB-SEM). Currently, projects are also underway to develop computer applications for the registration and segmentation of the serially-captured electron micrographs that are suitable for analyzing large volume EM data sets thoroughly and efficiently. The analysis of large volume data sets can bring innovative research results. These recently available techniques promote our understanding of the functional architecture of the brain.

Citing Articles

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