Skeletal Morbidity in Children and Adolescents During and Following Cancer Therapy

Overview

Journal Horm Res Paediatr

Publisher Karger

Specialties Endocrinology
Pediatrics

Date 2018 Nov 28

PMID 30481777

Citations 22

Authors

Sogol Mostoufi-Moab

Leanne M Ward

Affiliations

Soon will be listed here.

Abstract

Skeletal abnormalities are common in children and adolescents diagnosed and treated for a malignancy. The spectrum ranges from mild pain to debilitating osteonecrosis and fractures. In this review, we summarize the impact of cancer therapy on the developing skeleton, provide an update on therapeutic strategies for prevention and treatment, and discuss the most recent advances in musculoskeletal research. Early recognition of skeletal abnormalities and strategies to optimize bone health are essential to prevent long-term skeletal sequelae and diminished quality of life in childhood cancer survivors.

Citing Articles

Epidemiology of multimorbidity in childhood cancer survivors: a matched cohort study of inpatient hospitalisations in Western Australia.

Abdalla T, Ohan J, Ives A, White D, Choong C, Bulsara M BJC Rep. 2025; 3(1):15.

PMID: 40082620 PMC: 11906868. DOI: 10.1038/s44276-024-00114-1.

Paediatric cancer survivors: lean mass attenuates negative impact of watching television on bone.

Marmol-Perez A, Ubago-Guisado E, Llorente-Cantarero F, Cadenas-Sanchez C, Rodriguez-Solana A, Gil-Cosano J Pediatr Res. 2024; .

PMID: 39516571 DOI: 10.1038/s41390-024-03714-2.

Bone health in childhood cancer survivors, is there really a problem? Pitfalls of assessment, calculating risk, and suggested surveillance and management for osteonecrosis and low and very low bone mineral density.

de Winter D, Neggers S, van den Heuvel-Eibrink M, van Atteveld J Endocr Connect. 2024; 13(12).

PMID: 39437150 PMC: 11623254. DOI: 10.1530/EC-24-0487.

Osteoporosis and Bone Fragility in Children: Diagnostic and Treatment Strategies.

Cannalire G, Biasucci G, Bertolini L, Patianna V, Petraroli M, Pilloni S J Clin Med. 2024; 13(16).

PMID: 39201093 PMC: 11355204. DOI: 10.3390/jcm13164951.

Causality between Sex Hormones and Bone Mineral Density in Childhood: Age- and Tanner-Stage-Matched Sex Hormone Level May Be an Early Indicator of Pediatric Bone Fragility.

Kim S, Kim S, Kim S, Cho W, Cho K, Jung M Biomedicines. 2024; 12(6).

PMID: 38927380 PMC: 11200954. DOI: 10.3390/biomedicines12061173.

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