Understanding Neonatal Hypoxic-ischemic Encephalopathy with Metabolomics

Overview

Journal Hippokratia

Specialty General Medicine

Date 2018 Nov 28

PMID 30479472

Citations 9

Authors

N Efstathiou

G Theodoridis

K Sarafidis

Affiliations

Soon will be listed here.

Abstract

Background: Hypoxic-ischemic encephalopathy (HIE), a serious complication of perinatal asphyxia, is commonly associated with an unfavorable outcome. In-depth research is important not only for the interpretation of the underlying biological alternations but may also provide the basis for the development of novel diagnostic and therapeutic tools. The application of metabolomics in perinatal asphyxia/HIE is a relatively new approach.

Methods: We performed a narrative, non-systematic review in the literature of metabolomic studies involving newborn animals and humans exposed to hypoxia-ischemia or developing perinatal asphyxia/HIE.

Results: Fifteen animal studies, nine studies in human neonates, and two review articles were evaluated. Changes in the metabolomic profile of newborn animals exposed to hypoxia-ischemia and of asphyxiated neonates with HIE are presented in relation to the underlying pathophysiology. The clinical relevance of these findings is further discussed in a comprehensible to the bedside clinician manner.

Conclusions: Metabolomics may provide an explanation for the various metabolic alternations occurring in perinatal asphyxia/HIE, elucidate the biological background of the applied therapeutic interventions and promote the development of novel diagnostic-prognostic biomarkers of the disease. HIPPOKRATIA 2017, 21(3): 115-123.

Citing Articles

Antioxidant Therapy in Neonatal Hypoxic Ischemic Encephalopathy: Adjuvant or Future Alternative to Therapeutic Hypothermia?.

Notarbartolo V, Badiane B, Angileri V, Piro E, Giuffre M Metabolites. 2024; 14(11).

PMID: 39590867 PMC: 11596076. DOI: 10.3390/metabo14110630.

Incidence and predictors of mortality among neonates admitted with birth asphyxia to neonatal intensive care unit of West Shewa Zone Public Hospitals, Central Ethiopia.

Bekele G, Roga E, Gonfa D, Geda G BMJ Paediatr Open. 2024; 8(1).

PMID: 38580447 PMC: 11002380. DOI: 10.1136/bmjpo-2023-002403.

Metabolite Biomarkers for Early Ischemic-Hypoxic Encephalopathy: An Experimental Study Using the NeoBase 2 MSMS Kit in a Rat Model.

Shevtsova Y, Starodubtseva N, Tokareva A, Goryunov K, Sadekova A, Vedikhina I Int J Mol Sci. 2024; 25(4).

PMID: 38396712 PMC: 10888647. DOI: 10.3390/ijms25042035.

Diagnostic and Therapeutic Roles of the "Omics" in Hypoxic-Ischemic Encephalopathy in Neonates.

Rasineni G, Panigrahy N, Rath S, Chinnaboina M, Konanki R, Chirla D Bioengineering (Basel). 2022; 9(10).

PMID: 36290466 PMC: 9598631. DOI: 10.3390/bioengineering9100498.

Serum neuron-specific enolase, magnetic resonance imaging, and electrophysiology for predicting neurodevelopmental outcomes of neonates with hypoxic-ischemic encephalopathy: a prospective study.

Huang H, Hu X, Wen X, Yang L BMC Pediatr. 2022; 22(1):290.

PMID: 35581579 PMC: 9112575. DOI: 10.1186/s12887-022-03329-8.

References

Noto A, Fanos V, Dessi A . Metabolomics in Newborns. Adv Clin Chem. 2016; 74:35-61. DOI: 10.1016/bs.acc.2015.12.006. View

Jane Hassell K, Ezzati M, Alonso-Alconada D, Hausenloy D, Robertson N . New horizons for newborn brain protection: enhancing endogenous neuroprotection. Arch Dis Child Fetal Neonatal Ed. 2015; 100(6):F541-52. PMC: 4680177. DOI: 10.1136/archdischild-2014-306284. View

Noto A, Pomero G, Mussap M, Barberini L, Fattuoni C, Palmas F . Urinary gas chromatography mass spectrometry metabolomics in asphyxiated newborns undergoing hypothermia: from the birth to the first month of life. Ann Transl Med. 2016; 4(21):417. PMC: 5124630. DOI: 10.21037/atm.2016.11.27. View

White C, Doherty D, Henderson J, Kohan R, Newnham J, Pennell C . Accurate prediction of hypoxic-ischaemic encephalopathy at delivery: a cohort study. J Matern Fetal Neonatal Med. 2012; 25(9):1653-9. DOI: 10.3109/14767058.2011.653421. View

Liu J, Sheldon R, Segal M, Kelly M, Pelton J, Ferriero D . 1H nuclear magnetic resonance brain metabolomics in neonatal mice after hypoxia-ischemia distinguished normothermic recovery from mild hypothermia recoveries. Pediatr Res. 2013; 74(2):170-9. PMC: 3734529. DOI: 10.1038/pr.2013.88. View

Van Cappellen van Walsum A, Jongsma H, Wevers R, Nijhuis J, Crevels J, Engelke U . Hypoxia in fetal lambs: a study with (1)H-MNR spectroscopy of cerebrospinal fluid. Pediatr Res. 2001; 49(5):698-704. DOI: 10.1203/00006450-200105000-00015. View

Hauhart R, Jones E, Ikossi M, Pierce R . Decrease in brain glucose in anoxia in spite of elevated plasma glucose levels. Pediatr Res. 1973; 7(8):691-5. DOI: 10.1203/00006450-197308000-00003. View

Wyckoff M, Aziz K, Escobedo M, Kapadia V, Kattwinkel J, Perlman J . Part 13: Neonatal Resuscitation: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation. 2015; 132(18 Suppl 2):S543-60. DOI: 10.1161/CIR.0000000000000267. View

Shah S, Tracy M, Smyth J . Postnatal lactate as an early predictor of short-term outcome after intrapartum asphyxia. J Perinatol. 2004; 24(1):16-20. DOI: 10.1038/sj.jp.7211023. View

10.

Reinke S, Walsh B, Boylan G, Sykes B, Kenny L, Murray D . 1H NMR derived metabolomic profile of neonatal asphyxia in umbilical cord serum: implications for hypoxic ischemic encephalopathy. J Proteome Res. 2013; 12(9):4230-9. DOI: 10.1021/pr400617m. View

11.

Brown A, Tulina N, Barila G, Hester M, Elovitz M . Exposure to intrauterine inflammation alters metabolomic profiles in the amniotic fluid, fetal and neonatal brain in the mouse. PLoS One. 2017; 12(10):e0186656. PMC: 5648237. DOI: 10.1371/journal.pone.0186656. View

12.

Jacobs S, Berg M, Hunt R, Tarnow-Mordi W, Inder T, Davis P . Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev. 2013; (1):CD003311. PMC: 7003568. DOI: 10.1002/14651858.CD003311.pub3. View

13.

Lawn J, Cousens S, Zupan J . 4 million neonatal deaths: when? Where? Why?. Lancet. 2005; 365(9462):891-900. DOI: 10.1016/S0140-6736(05)71048-5. View

14.

Johnston M . Excitotoxicity in perinatal brain injury. Brain Pathol. 2005; 15(3):234-40. PMC: 8095755. DOI: 10.1111/j.1750-3639.2005.tb00526.x. View

15.

Pietz J, Guttenberg N, Gluck L . Hypoxanthine: a marker for asphyxia. Obstet Gynecol. 1988; 72(5):762-6. View

16.

Tapiero H, MATHE G, Couvreur P, Tew K . II. Glutamine and glutamate. Biomed Pharmacother. 2002; 56(9):446-57. DOI: 10.1016/s0753-3322(02)00285-8. View

17.

Fanos V, Noto A, Xanthos T, Lussu M, Murgia F, Barberini L . Metabolomics network characterization of resuscitation after normocapnic hypoxia in a newborn piglet model supports the hypothesis that room air is better. Biomed Res Int. 2014; 2014:731620. PMC: 3947697. DOI: 10.1155/2014/731620. View

18.

Vannucci R . Cerebral carbohydrate and energy metabolism in perinatal hypoxic-ischemic brain damage. Brain Pathol. 1992; 2(3):229-34. DOI: 10.1111/j.1750-3639.1992.tb00696.x. View

19.

Chu C, Xiao X, Zhou X, Lau T, Rogers M, Fok T . Metabolomic and bioinformatic analyses in asphyxiated neonates. Clin Biochem. 2006; 39(3):203-9. DOI: 10.1016/j.clinbiochem.2006.01.006. View

20.

Theodoridis G, Gika H, Want E, Wilson I . Liquid chromatography-mass spectrometry based global metabolite profiling: a review. Anal Chim Acta. 2011; 711:7-16. DOI: 10.1016/j.aca.2011.09.042. View