Eicosanoid and Specialized Proresolving Mediator Regulation of Lymphoid Cells

Overview

Journal Trends Biochem Sci

Specialty Biochemistry

Date 2018 Nov 28

PMID 30477730

Citations 21

Authors

Jessica Wei

Karsten Gronert

Affiliations

Soon will be listed here.

Abstract

Eicosanoids and specialized proresolving mediators (SPMs) regulate leukocyte function and inflammation. They are ideally positioned at the interface of the innate and adaptive immune responses when lymphocytes interact with leukocytes. Receptors for leukotriene B (LTB), prostaglandin E (PGE), and SPMs are expressed on lymphocytes. Evidence points toward an essential role of these lipid mediators (LMs) in direct regulation of lymphocyte functions. SPMs, which include lipoxins, demonstrate comprehensive protective actions with lymphocytes. LTB and PGE regulation of lymphocytes is diverse and depends on the interaction of lymphocytes with other cells. Importantly, both LTB and PGE are essential regulators of T cell antitumor activity. These LMs are attractive therapeutic targets to control dysregulated innate and adaptive immune responses, promote lymphocyte antitumor activity, and prevent tumor immune evasion.

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