A3 Foresight Network on Natural Products

Overview

Journal J Ind Microbiol Biotechnol

Publisher Oxford University Press

Specialty Biotechnology

Date 2018 Nov 27

PMID 30474768

Authors

Linquan Bai

Yasuo Ohnishi

Eung-Soo Kim

Affiliations

Soon will be listed here.

Abstract

Discovery and development of natural products (NPs) have played important roles in the fields of human medicine and other biotechnology fields for the past several decades. Recent genome-mining approaches for the isolation of novel and cryptic NP biosynthetic gene clusters (BGCs) have led to the growing interest in NP research communities including Asian NP researchers from China, Japan, and Korea. Recently, a three-nation government-sponsored program named 'A3 Foresight Network on Chemical and Synthetic Biology of NPs' has been launched with a goal of establishing an Asian hub for NP research-&-personnel exchange program. This brief commentary describes introduction, main researchers, and future perspective of A3 NP network program.

References

Arakawa K, Tsuda N, Taniguchi A, Kinashi H . The butenolide signaling molecules SRB1 and SRB2 induce lankacidin and lankamycin production in Streptomyces rochei. Chembiochem. 2012; 13(10):1447-57. DOI: 10.1002/cbic.201200149. View

Maruyama C, Toyoda J, Kato Y, Izumikawa M, Takagi M, Shin-Ya K . A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis. Nat Chem Biol. 2012; 8(9):791-7. DOI: 10.1038/nchembio.1040. View

Bachmann B, Van Lanen S, Baltz R . Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?. J Ind Microbiol Biotechnol. 2013; 41(2):175-84. PMC: 4070288. DOI: 10.1007/s10295-013-1389-9. View

Muliandi A, Katsuyama Y, Sone K, Izumikawa M, Moriya T, Hashimoto J . Biosynthesis of the 4-methyloxazoline-containing nonribosomal peptides, JBIR-34 and -35, in Streptomyces sp. Sp080513GE-23. Chem Biol. 2014; 21(8):923-34. DOI: 10.1016/j.chembiol.2014.06.004. View

Jiang C, Qi Z, Kang Q, Liu J, Jiang M, Bai L . Formation of the Δ(18,19) Double Bond and Bis(spiroacetal) in Salinomycin Is Atypically Catalyzed by SlnM, a Methyltransferase-like Enzyme. Angew Chem Int Ed Engl. 2015; 54(31):9097-100. PMC: 4744726. DOI: 10.1002/anie.201503561. View

Kim E, Moore B, Yoon Y . Reinvigorating natural product combinatorial biosynthesis with synthetic biology. Nat Chem Biol. 2015; 11(9):649-59. PMC: 4757526. DOI: 10.1038/nchembio.1893. View

Baltz R . Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes. J Ind Microbiol Biotechnol. 2015; 43(2-3):343-70. DOI: 10.1007/s10295-015-1682-x. View

Sugai Y, Katsuyama Y, Ohnishi Y . A nitrous acid biosynthetic pathway for diazo group formation in bacteria. Nat Chem Biol. 2015; 12(2):73-5. DOI: 10.1038/nchembio.1991. View

Katz L, Baltz R . Natural product discovery: past, present, and future. J Ind Microbiol Biotechnol. 2016; 43(2-3):155-76. DOI: 10.1007/s10295-015-1723-5. View

10.

Shi G, Shi N, Li Y, Chen W, Deng J, Liu C . D-Alanylation in the Assembly of Ansatrienin Side Chain Is Catalyzed by a Modular NRPS. ACS Chem Biol. 2016; 11(4):876-81. DOI: 10.1021/acschembio.6b00004. View

11.

Kong D, Zou Y, Zhang Z, Xu F, Brock N, Zhang L . Identification of (2S,3S)-β-Methyltryptophan as the Real Biosynthetic Intermediate of Antitumor Agent Streptonigrin. Sci Rep. 2016; 6:20273. PMC: 4742848. DOI: 10.1038/srep20273. View

12.

Newman D, Cragg G . Natural Products as Sources of New Drugs from 1981 to 2014. J Nat Prod. 2016; 79(3):629-61. DOI: 10.1021/acs.jnatprod.5b01055. View

13.

Lu C, Zhang X, Jiang M, Bai L . Enhanced salinomycin production by adjusting the supply of polyketide extender units in Streptomyces albus. Metab Eng. 2016; 35:129-137. DOI: 10.1016/j.ymben.2016.02.012. View

14.

Maruyama C, Niikura H, Izumikawa M, Hashimoto J, Shin-Ya K, Komatsu M . tRNA-Dependent Aminoacylation of an Amino Sugar Intermediate in the Biosynthesis of a Streptothricin-Related Antibiotic. Appl Environ Microbiol. 2016; 82(12):3640-8. PMC: 4959175. DOI: 10.1128/AEM.00725-16. View

15.

Jeong Y, Kim J, Kim M, Bucca G, Cho S, Yoon Y . The dynamic transcriptional and translational landscape of the model antibiotic producer Streptomyces coelicolor A3(2). Nat Commun. 2016; 7:11605. PMC: 4895711. DOI: 10.1038/ncomms11605. View

16.

Xu M, Wang Y, Zhao Z, Gao G, Huang S, Kang Q . Functional Genome Mining for Metabolites Encoded by Large Gene Clusters through Heterologous Expression of a Whole-Genome Bacterial Artificial Chromosome Library in Streptomyces spp. Appl Environ Microbiol. 2016; 82(19):5795-805. PMC: 5038051. DOI: 10.1128/AEM.01383-16. View

17.

Ozaki T, Yamashita K, Goto Y, Shimomura M, Hayashi S, Asamizu S . Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo. Nat Commun. 2017; 8:14207. PMC: 5303826. DOI: 10.1038/ncomms14207. View

18.

Nah H, Pyeon H, Kang S, Choi S, Kim E . Cloning and Heterologous Expression of a Large-sized Natural Product Biosynthetic Gene Cluster in Species. Front Microbiol. 2017; 8:394. PMC: 5350119. DOI: 10.3389/fmicb.2017.00394. View

19.

Zheng X, Cheng Q, Yao F, Wang X, Kong L, Cao B . Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps. Proc Natl Acad Sci U S A. 2017; 114(16):4135-4140. PMC: 5402462. DOI: 10.1073/pnas.1701361114. View

20.

Onaka H . Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetes. J Antibiot (Tokyo). 2017; 70(8):865-870. DOI: 10.1038/ja.2017.51. View