Recent Advances in Imaging and Understanding Interstitial Cystitis

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2018 Nov 27

PMID 30473772

Citations 9

Authors

Pradeep Tyagi

Chan-Hong Moon

Joseph Janicki

Jonathan Kaufman

Michael Chancellor

Naoki Yoshimura

Christopher Chermansky

Affiliations

Soon will be listed here.

Abstract

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating condition associated with intense pelvic pain and bladder storage symptoms. Since diagnosis is difficult, prevalence estimates vary with the methodology used. There is also a lack of proven imaging tools and biomarkers to assist in differentiation of IC/BPS from other urinary disorders (overactive bladder, vulvodynia, endometriosis, and prostatitis). Current uncertainty regarding the etiology and pathology of IC/BPS ultimately impacts its timely and successful treatment, as well as hampers future drug development. This review will cover recent developments in imaging methods, such as magnetic resonance imaging, that advance the understanding of IC/BPS and guide drug development.

Citing Articles

Joint Terminology Report: Terminology Standardization for Female Bladder Pain Syndrome.

Int Urogynecol J. 2025; 36(2):265-277.

PMID: 39751633 DOI: 10.1007/s00192-024-05923-z.

Radiology of fibrosis part III: genitourinary system.

Tarchi S, Salvatore M, Lichtenstein P, Sekar T, Capaccione K, Luk L J Transl Med. 2024; 22(1):616.

PMID: 38961396 PMC: 11223291. DOI: 10.1186/s12967-024-05333-1.

TGF-β inhibitor treatment of H₂O₂-induced cystitis models provides biochemical mechanism for elucidating interstitial cystitis/painful bladder syndrome patients.

Taga H, Kishida T, Inoue Y, Yamamoto K, Kotani S, Masashi T PLoS One. 2023; 18(11):e0293983.

PMID: 37931000 PMC: 10627456. DOI: 10.1371/journal.pone.0293983.

Intravesical Contrast-Enhanced MRI: A Potential Tool for Bladder Cancer Surveillance and Staging.

Tyagi P, Moon C, Connell M, Ganguly A, Cho K, Tarin T Curr Oncol. 2023; 30(5):4632-4647.

PMID: 37232808 PMC: 10217503. DOI: 10.3390/curroncol30050350.

Molecular Mechanisms and Key Processes in Interstitial, Hemorrhagic and Radiation Cystitis.

Brossard C, Lefranc A, Pouliet A, Simon J, Benderitter M, Milliat F Biology (Basel). 2022; 11(7).

PMID: 36101353 PMC: 9311586. DOI: 10.3390/biology11070972.

References

Slobodov G, Feloney M, Gran C, Kyker K, Hurst R, Culkin D . Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis. J Urol. 2004; 171(4):1554-8. DOI: 10.1097/01.ju.0000118938.09119.a5. View

Takeda K, Kawaguchi T, Shiraishi T, Kobayashi S, Hayashi N, Yanagawa M . Normal bladder wall morphology in Gd-DTPA-enhanced clinical MR imaging using an endorectal surface coil and histological assessment of submucosal linear enhancement using [14C]Gd-DOTA autoradiography in an animal model. Eur J Radiol. 1998; 26(3):290-6. DOI: 10.1016/s0720-048x(97)01178-9. View

Colaco M, Koslov D, Keys T, Evans R, Badlani G, Andersson K . Correlation of gene expression with bladder capacity in interstitial cystitis/bladder pain syndrome. J Urol. 2014; 192(4):1123-9. DOI: 10.1016/j.juro.2014.05.047. View

Tang S, Cao G, Mao Y, Wang Y, Li S, Yang Y . Clinical value of pelvic 3-dimensional magnetic resonance image reconstruction in anorectal malformations. J Pediatr Surg. 2009; 44(12):2369-74. DOI: 10.1016/j.jpedsurg.2009.07.074. View

Walker S, Zambon J, Andersson K, Langefeld C, Matthews C, Badlani G . Bladder Capacity is a Biomarker for a Bladder Centric versus Systemic Manifestation in Interstitial Cystitis/Bladder Pain Syndrome. J Urol. 2017; 198(2):369-375. DOI: 10.1016/j.juro.2017.02.022. View

Fu Y, Tanaka K, Nishimura S . Evaluation of brain edema using magnetic resonance proton relaxation times. Adv Neurol. 1990; 52:165-76. View

Ma Z, Jorge R, Mascarenhas T, R S Tavares J . Novel approach to segment the inner and outer boundaries of the bladder wall in T2-weighted magnetic resonance images. Ann Biomed Eng. 2011; 39(8):2287-97. DOI: 10.1007/s10439-011-0324-3. View

Peters K, Jayabalan N, Bui D, Killinger K, Chancellor M, Tyagi P . Effect of Sacral Neuromodulation on Outcome Measures and Urine Chemokines in Interstitial Cystitis/Painful Bladder Syndrome Patients. Low Urin Tract Symptoms. 2015; 7(2):77-83. DOI: 10.1111/luts.12054. View

Babcock E, Brateman L, Weinreb J, Horner S, Nunnally R . Edge artifacts in MR images: chemical shift effect. J Comput Assist Tomogr. 1985; 9(2):252-7. DOI: 10.1097/00004728-198503000-00004. View

10.

Nguyen H, Pohar K, Jia G, Shah Z, Mortazavi A, Zynger D . Improving bladder cancer imaging using 3-T functional dynamic contrast-enhanced magnetic resonance imaging. Invest Radiol. 2014; 49(6):390-5. PMC: 4326253. DOI: 10.1097/RLI.0000000000000022. View

11.

Kirkemo A, Peabody M, Diokno A, Afanasyev A, Nyberg Jr L, Landis J . Associations among urodynamic findings and symptoms in women enrolled in the Interstitial Cystitis Data Base (ICDB) Study. Urology. 1997; 49(5A Suppl):76-80. DOI: 10.1016/s0090-4295(99)80335-5. View

12.

Doiron R, Tolls V, Irvine-Bird K, Kelly K, Nickel J . Clinical Phenotyping Does Not Differentiate Hunner Lesion Subtype of Interstitial Cystitis/Bladder Pain Syndrome: A Relook at the Role of Cystoscopy. J Urol. 2016; 196(4):1136-40. DOI: 10.1016/j.juro.2016.04.067. View

13.

Wennevik G, Meijlink J, Hanno P, Nordling J . The Role of Glomerulations in Bladder Pain Syndrome: A Review. J Urol. 2015; 195(1):19-25. DOI: 10.1016/j.juro.2015.06.112. View

14.

Doggweiler R, Whitmore K, Meijlink J, Drake M, Frawley H, Nordling J . A standard for terminology in chronic pelvic pain syndromes: A report from the chronic pelvic pain working group of the international continence society. Neurourol Urodyn. 2016; 36(4):984-1008. DOI: 10.1002/nau.23072. View

15.

Nickel J, Crossland A, Davis E, Haab F, Mills I, Rovner E . Investigation of a Ca2+ channel α2δ ligand for the treatment of interstitial cystitis: results of a randomized, double-blind, placebo controlled phase II trial. J Urol. 2012; 188(3):817-23. DOI: 10.1016/j.juro.2012.05.010. View

16.

Chung C, Zhang Q, Qiao L . Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis. J Biol Chem. 2009; 285(6):4206-4212. PMC: 2823559. DOI: 10.1074/jbc.M109.040444. View

17.

Weissleder R, Ntziachristos V . Shedding light onto live molecular targets. Nat Med. 2003; 9(1):123-8. DOI: 10.1038/nm0103-123. View

18.

Nickel J, Hanno P, Kumar K, Thomas H . Second multicenter, randomized, double-blind, parallel-group evaluation of effectiveness and safety of intravesical sodium chondroitin sulfate compared with inactive vehicle control in subjects with interstitial cystitis/bladder pain syndrome. Urology. 2012; 79(6):1220-4. DOI: 10.1016/j.urology.2012.01.059. View

19.

Theoharides T, Sant G, Letourneau R, Ucci Jr A, Meares Jr E . Activation of bladder mast cells in interstitial cystitis: a light and electron microscopic study. J Urol. 1995; 153(3 Pt 1):629-36. DOI: 10.1097/00005392-199503000-00021. View

20.

Tung A, Hepp Z, Bansal A, Devine E . Characterizing Health Care Utilization, Direct Costs, and Comorbidities Associated with Interstitial Cystitis: A Retrospective Claims Analysis. J Manag Care Spec Pharm. 2017; 23(4):474-482. PMC: 10397899. DOI: 10.18553/jmcp.2017.23.4.474. View