Porcine Endemic Diarrhea Virus Infection Regulates Long Noncoding RNA Expression

Overview

Journal Virology

Specialty Microbiology

Date 2018 Nov 25

PMID 30471453

Citations 12

Authors

Jianing Chen

Chenyu Zhang

Na Zhang

Guangliang Liu

Affiliations

Soon will be listed here.

Abstract

Long noncoding RNAs (lncRNAs) have been implicated in various life processes. However, the lncRNA expression and potential functions in porcine endemic diarrhea virus (PEDV) infection and host defense are still poorly understood. In this study, we investigated the lncRNA expression profiles during PEDV infection in intestinal porcine epithelial cell-jejunum 2 (IPEC-J2) cell lines by next-generation sequencing and identified 6188 novel lncRNAs. The functional annotation analysis revealed that these lncRNAs might be associated with many immunity-related genes. We next selected candidate lncRNAs related to immune response pathways and further identified their differential expression in PEDV-infected IPEC-J2 cells and newborn piglets. Our results demonstrated that PEDV infection regulated lncRNA expression patterns in both the IPEC-J2 cell line and piglet ileum. These findings provide the first large-scale survey of lncRNAs associated with PEDV infection, specifically the lncRNAs responsible for the activation of the immune system within the ileum.

Citing Articles

Unveiling the Role of Protein Kinase C θ in Porcine Epidemic Diarrhea Virus Replication: Insights from Genome-Wide CRISPR/Cas9 Library Screening.

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PMID: 38542067 PMC: 10969977. DOI: 10.3390/ijms25063096.

Transcriptomics yields valuable information regarding the response mechanisms of Chinese Min pigs infected with PEDV.

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METTL3-Mediated LncRNA m6A Modification Alleviates CPB2 Toxin-Induced Damage in IPEC-J2 Cells.

Yang J, Yang Q, Huang X, Yan Z, Wang P, Gao X Int J Mol Sci. 2023; 24(6).

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Genome-Wide Analysis of Long Noncoding RNAs in Porcine Intestine during Weaning Stress.

Liu S, Tao X, Deng B, Li Y, Xu Z Int J Mol Sci. 2023; 24(6).

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LncRNA promotes CPB2-induced proliferation and inhibits apoptosis in IPEC-J2 cells by affecting the JAK-STAT signaling pathway activation.

Yang J, Zhang J, Yang Q, Huang X, Yan Z, Wang P Front Microbiol. 2023; 13:1082025.

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