Organophosphine-Catalyzed [4C+X] Annulations

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 Nov 23

PMID 30463230

Authors

Yangyan Li

Xiang Chen

Xiaoming Chen

Xiao Shen

Affiliations

Soon will be listed here.

Abstract

In recent years, there have been extraordinary developments of organophosphine-catalyzed reactions. This includes progress in the area of [4C+X] annulations, which are of particular interest due to their potential for the rapid construction of 5⁻8-membered cyclic products. In this short overview, we summarize the remarkable progress, emphasizing reaction mechanisms and key intermediates involved in the processes. The discussion is classified according to the type of electrophilic reactants that acted as ₄ synthons in the annulation process, in the order of α-alkyl allenoates, γ-alkyl allenoates, α-methyl allene ketones, β'-OAc allenoate, δ-OAc allenoate, activated dienes and cyclobutenones.

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