Limitation of Excessive Myelopoiesis by the Intrinsic Modulation of Macrophage-derived Prostaglandin E

Overview

Journal Science

Specialty Science

Date 1978 Feb 3

PMID 304600

Citations 42

Authors

J I Kurland

R S Bockman

H E Broxmeyer

M A Moore

Affiliations

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Abstract

The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.

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