Appearance of CNS Histoplasmosis on F-FDG PET/CT with MRI Correlation
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Disseminated histoplasmosis is an opportunistic infection encountered in immunocompromised patients such as those with human immunodeficiency virus infection/acquired immune deficiency syndrome. Involvement of the central nervous system (CNS) can occur in 5-20% of cases of disseminated histoplasmosis, and CNS histoplasmosis can be very difficult to diagnose conventional imaging modalities such as CT or MRI. The role of F-fludeoxyglucose positron emission tomography/CT scan in the diagnosis of CNS histoplasmosis has not been established. A 66-year-old female presented with dizziness and unsteady gait and was diagnosed with human immunodeficiency virus infection and CNS histoplasmosis. In this report, we present the MRI and F-fludeoxyglucose positron emission tomography/CT image findings.
Rossi D, Figueroa J, Buesing W, Candor K, Blancett L, Evans H J Clin Invest. 2021; 131(16).
PMID: 34237029 PMC: 8363289. DOI: 10.1172/JCI147268.