Genetic Basis of Variation in Heat and Ethanol Tolerance in

Overview

Journal G3 (Bethesda)

Publisher Oxford University Press

Specialties Genetics
Molecular Biology

Date 2018 Nov 22

PMID 30459179

Citations 7

Authors

Linda Riles

Justin C Fay

Affiliations

Soon will be listed here.

Abstract

has the capability of fermenting sugar to produce concentrations of ethanol that are toxic to most organisms. Other species also have a strong fermentative capacity, but some are specialized to low temperatures, whereas is the most thermotolerant. Although has been extensively used to study the genetic basis of ethanol tolerance, much less is known about temperature dependent ethanol tolerance. In this study, we examined the genetic basis of ethanol tolerance at high temperature among strains of We identified two amino acid polymorphisms in that cause strong sensitivity to ethanol at high temperature and more limited sensitivity to temperature in the absence of ethanol. We also identified a single amino acid polymorphism in that causes sensitivity to high temperature in a strain dependent fashion. The genes we identified provide further insight into genetic variation in ethanol and temperature tolerance and the interdependent nature of these two traits in .

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