Long-Term Outcomes of Kidney Transplantation in Children

Overview

Journal Pediatr Clin North Am

Specialty Pediatrics

Date 2018 Nov 21

PMID 30454748

Citations 21

Authors

Pamela D Winterberg

Rouba Garro

Affiliations

Soon will be listed here.

Abstract

Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD) in children and confers improved survival, skeletal growth, heath-related quality of life, and neuropsychological development compared with dialysis. Kidney transplantation in children with ESRD results in 10-year patient survival exceeding 90%. Therefore, the long-term management of these patients is focused on maintaining quality of life and minimizing long-term side effects of immunosuppression. Optimal management of pediatric kidney transplant recipients includes preventing rejection and infection, identifying and reducing the cardiovascular and metabolic effects of long-term immunosuppressive therapy, supporting normal growth and development, and managing a smooth transition into adulthood.

Citing Articles

Identifying Risk Factors for Graft Failure due to Chronic Rejection < 15 Years Post-Transplant in Pediatric Kidney Transplants Using Random Forest Machine-Learning Techniques.

Suh H Pediatr Transplant. 2025; 29(2):e70043.

PMID: 39981772 PMC: 11843590. DOI: 10.1111/petr.70043.

Second kidney transplant during childhood: clinical aspects, outcomes, and risk factors for graft survival.

de Santis Feltran L, Hamamoto F, Genzani C, Fonseca M, de Carvalho M, Koch-Nogueira P Pediatr Nephrol. 2025; .

PMID: 39954072 DOI: 10.1007/s00467-025-06685-6.

Evaluating Activated Regulatory T Cells as a Biomarker of Chronic Allograft Inflammation in Pediatric Kidney Transplant Recipients.

Leung M, Barrett-Chan E, Levings M, Vercauteren S, Blydt-Hansen T Pediatr Transplant. 2025; 29(2):e70041.

PMID: 39924341 PMC: 11807789. DOI: 10.1111/petr.70041.

Follow-up biopsies with microvascular inflammation and persistent donor specific antibodies identify ongoing rejection in pediatric kidney transplant recipients.

Crane C, Mehrabli J, Ellington N, Shayan K, Morris G, Ingulli E Pediatr Nephrol. 2025; .

PMID: 39873804 DOI: 10.1007/s00467-025-06671-y.

Prediction of Allograft Failure in Pediatric Kidney Transplant Recipients: A Validation Study of the Four-Variable Kidney Failure Risk Equation.

Nogueira Machado S, Freitas J, Moreira C, Teixeira A, Costa T, Faria M Cureus. 2024; 16(11):e72901.

PMID: 39624526 PMC: 11611478. DOI: 10.7759/cureus.72901.

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