Efficient Preparation of Various O-Methylquercetins by Selective Demethylation

Overview

Journal Nat Prod Commun

Publisher Sage Publications

Date 2018 Nov 20

PMID 30452171

Citations 2

Authors

Yuki Kimura

Ryo Kato

Kin-Ichi Oyama

Tadao Kondo

Kumi Yoshida

Affiliations

Soon will be listed here.

Abstract

penia-O-Methylquercetin (2) was prepared by permethylation of quercetin (1). Selective demethylation of 2 using either BBr or BCl3/TBAI (tetrabutylammonium iodide) gave five O-methylquercetins (3-6), with satisfactory yields. The reaction can be easily scaled-up. We established an efficient and large-scale preparation of O-methylquercetins.

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