Sex Hormone Receptor Expression and Survival in Esophageal Adenocarcinoma: a Prospective Cohort Study

Overview

Journal Oncotarget

Specialty Oncology

Date 2018 Nov 20

PMID 30450159

Citations 5

Authors

Una C McMenamin

James Trainor

Helen G Coleman

Damian T McManus

Stephen McQuaid

Victoria Bingham

Jacqueline James

Manuel Salto-Tellez

Brian T Johnston

Richard C Turkington

Affiliations

Soon will be listed here.

Abstract

Introduction: A striking epidemiological feature of esophageal adenocarcinoma (EAC) is its strong, unexplained male predominance but few studies have evaluated the prevalence of sex hormone receptor expression in EAC.

Results: A low proportion of EAC tumors stained positive for ERα (4%) and AR (3%) while approximately one third stained positive for ERβ (31%). After a mean follow-up of 3 years (max 9 years), no significant associations were seen for ERα, ERβ or AR expression and EAC recurrence or survival. A non-significant reduction in mortality was observed for positive ERβ tumor expression, when restricting to patients with gastro-esophageal junctional (GEJ) cancer (HR 0.58, 95% CI 0.33, 1.03, = 0.06).

Materials And Methods: We identified all EAC patients who underwent neo-adjuvant chemotherapy prior to surgical resection between 2004-2012 in the Northern Ireland Cancer Centre. Immunohistochemical expression of ERα, ERβ and AR was scored on triplicate cores to generate H-scores. Cox proportional hazards regression was used to evaluate the association between sex hormone receptor expression and overall, cancer-specific and recurrence-free survival.

Conclusion: We found little evidence of ERα or AR expression in EAC. A moderate proportion expressed ERβ and there was suggestive evidence that its expression was associated with improved survival in GEJ cancer patients.

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