Resected Thymic Large Cell Neuroendocrine Carcinoma: Report of a Case

Overview

Journal Surg Case Rep

Specialty General Surgery

Date 2018 Nov 18

PMID 30446840

Citations 2

Authors

Hiromitsu Domen

Yasuhiro Hida

Masaaki Sato

Haruka Takahashi

Tatsuru Ishikawa

Yosuke Shionoya

Midori Hashimoto

Kaoru Nishiyama

Yuma Aoki

Kazuho Inoko

Syotaro Furukawa

Kazuomi Ichinokawa

Hidehisa Yamada

Affiliations

Soon will be listed here.

Abstract

Background: Thymic large cell neuroendocrine carcinoma (LCNEC) is extremely rare. The detailed clinical features of thymic LNCECs remain unknown.

Case Presentation: A 90-year-old man with a history of diabetes mellitus, chronic renal failure, and an abdominal aortic aneurysm underwent computed tomography for follow-up, which showed an anterior mediastinal tumor, measuring 31 mm × 28 mm in diameter. Magnetic resonance imaging showed an iso-intensity mass on T1-weighted images and high intensity on T2-weighted images. 18F-Fluorodeoxyglucose-positron emission tomography showed marked uptake in the mass, which was diagnosed as invasive thymoma or thymic carcinoma. Video-assisted thoracic surgery through the left thoracic cavity was converted to median sternotomy due to severe adhesions between the left lung and the chest wall. Partial thymectomy and combined partial resection of left upper lobectomy and the first and the second costal cartilages were performed. The pathologic diagnosis was thymic LCNEC, Masaoka stage III. The patient developed pleural dissemination and left lung metastases in 5 months and died 12 months after surgery.

Conclusions: Thymic LCNEC has high malignant potential. More cases need to be studied.

Citing Articles

MRI Findings and Differential Diagnosis of Anterior Mediastinal Solid Tumors.

Nakazono T, Yamaguchi K, Egashira R, Iyadomi M, Fujiki K, Takayanagi S Magn Reson Med Sci. 2022; 22(4):415-433.

PMID: 35296589 PMC: 10552663. DOI: 10.2463/mrms.rev.2021-0098.

Resected thymic large cell neuroendocrine carcinoma: A case report and review of the literature.

Ogata S, Maeda R, Tomita M, Sato Y, Ayabe T, Nakamura K Int J Surg Case Rep. 2019; 60:53-57.

PMID: 31202999 PMC: 6580310. DOI: 10.1016/j.ijscr.2019.05.057.

References

Kriegsmann M, Muley T, Harms A, Tavernar L, Goldmann T, Dienemann H . Differential diagnostic value of CD5 and CD117 expression in thoracic tumors: a large scale study of 1465 non-small cell lung cancer cases. Diagn Pathol. 2015; 10:210. PMC: 4672573. DOI: 10.1186/s13000-015-0441-7. View

Cardillo G, Rea F, Lucchi M, Paul M, Margaritora S, Carleo F . Primary neuroendocrine tumors of the thymus: a multicenter experience of 35 patients. Ann Thorac Surg. 2012; 94(1):241-5. DOI: 10.1016/j.athoracsur.2012.03.062. View

Dorfman D, Shahsafaei A, Chan J . Thymic carcinomas, but not thymomas and carcinomas of other sites, show CD5 immunoreactivity. Am J Surg Pathol. 1997; 21(8):936-40. DOI: 10.1097/00000478-199708000-00008. View

Mega S, Oguri M, Kawasaki R, Hazama K, Iwai K, Kondo S . Large-cell neuroendocrine carcinoma in the thymus. Gen Thorac Cardiovasc Surg. 2008; 56(11):566-9. DOI: 10.1007/s11748-008-0299-7. View

Nagata Y, Ohno K, Utsumi T, Sasaki Y, Suzuki Y . Large cell neuroendocrine thymic carcinoma coexisting within large WHO type AB thymoma. Jpn J Thorac Cardiovasc Surg. 2006; 54(6):256-9. DOI: 10.1007/pl00022248. View

Wick M, Rosai J . Neuroendocrine neoplasms of the mediastinum. Semin Diagn Pathol. 1991; 8(1):35-51. View

Tiffet O, Nicholson A, Ladas G, Sheppard M, Goldstraw P . A clinicopathologic study of 12 neuroendocrine tumors arising in the thymus. Chest. 2003; 124(1):141-6. DOI: 10.1378/chest.124.1.141. View

Ogawa F, Iyoda A, Amano H, Nezu K, Jiang S, Okayasu I . Thymic large cell neuroendocrine carcinoma: report of a resected case - a case report. J Cardiothorac Surg. 2010; 5:115. PMC: 2995793. DOI: 10.1186/1749-8090-5-115. View

Rosai J, Higa E . Mediastinal endocrine neoplasm, of probable thymic origin, related to carcinoid tumor. Clinicopathologic study of 8 cases. Cancer. 1972; 29(4):1061-74. DOI: 10.1002/1097-0142(197204)29:4<1061::aid-cncr2820290456>3.0.co;2-3. View

10.

Yasumoto T, Oizumi H, Katoh H, Inoue T, Sadahiro M . [Large cell neuroendocrine carcinoma of the thymus; report of a case]. Kyobu Geka. 2014; 67(3):251-4. View

11.

Ahn S, Lee J, Ha S, Sung C, Kim J, Han J . Clinicopathological analysis of 21 thymic neuroendocrine tumors. Korean J Pathol. 2012; 46(3):221-5. PMC: 3479770. DOI: 10.4132/KoreanJPathol.2012.46.3.221. View

12.

Asirvatham J, Esposito M, Bhuiya T . Role of PAX-8, CD5, and CD117 in distinguishing thymic carcinoma from poorly differentiated lung carcinoma. Appl Immunohistochem Mol Morphol. 2013; 22(5):372-6. DOI: 10.1097/PAI.0b013e318297cdb5. View

13.

Ose N, Inoue M, Morii E, Shintani Y, Sawabata N, Okumura M . Multimodality therapy for large cell neuroendocrine carcinoma of the thymus. Ann Thorac Surg. 2013; 96(4):e85-e87. DOI: 10.1016/j.athoracsur.2013.04.107. View

14.

Cardillo G, Treggiari S, Paul M, Carleo F, De Massimi A, Remotti D . Primary neuroendocrine tumours of the thymus: a clinicopathologic and prognostic study in 19 patients. Eur J Cardiothorac Surg. 2009; 37(4):814-8. DOI: 10.1016/j.ejcts.2009.10.026. View

15.

Saito T, Kimoto M, Nakai S, Ikoma A, Toyoshima H, Kawakami M . Ectopic ACTH syndrome associated with large cell neuroendocrine carcinoma of the thymus. Intern Med. 2011; 50(14):1471-5. DOI: 10.2169/internalmedicine.50.5160. View

16.

Dutta R, Kumar A, Jindal T, Mathur S . Neuroendocrine carcinoma of the thymus gland with sternal invasion. Interact Cardiovasc Thorac Surg. 2009; 8(6):694-6. DOI: 10.1510/icvts.2008.201020. View

17.

Yoon Y, Kim J, Kim K, Baek W, Lee H, Lee M . Large cell neuroendocrine carcinoma of the thymus: a two-case report. Korean J Thorac Cardiovasc Surg. 2012; 45(1):60-4. PMC: 3283788. DOI: 10.5090/kjtcs.2012.45.1.60. View