Association Between Body Fat and Bone Mineral Density in Normal-Weight Middle-Aged Koreans

Overview

Journal Korean J Fam Med

Specialty Public Health

Date 2018 Nov 17

PMID 30441887

Citations 10

Authors

Dong-Hyun Kim

Heekyung Lim

Seungbin Chang

Ju-No Kim

Yong-Kyun Roh

Min-Kyu Choi

Affiliations

Soon will be listed here.

Abstract

Background: Osteoporosis and osteopenia are characterized by reduced bone mineral density (BMD) and increased fracture risk. Although the risk of fractures is higher in underweight people than in overweight people, the accumulation of body fat (especially abdominal fat) can increase the risk of bone loss. This study aimed to evaluate the association between body fat percentage and BMD in normal-weight middle-aged Koreans.

Methods: This study included 1,992 adults (mean age, 48.7 years; 52.9% women). BMD and body fat were measured using dual-energy X-ray absorptiometry. Multiple linear regression analyses and analysis of covariance were used to assess the association between BMD and body fat. Body fat percentage was grouped by cut-off values. The cut-off values were 20.6% and 25.7% for men with a body mass index of 18.5-22.9 kg/m2 , while the cut-off values were 33.4% and 36% for women.

Results: Body fat percentage tended to be negatively associated with BMD. Increased body fat percentage was associated with reduced BMD in normal-weight middle-aged adults. The effects of body fat percentage on BMD in normal-weight individuals were more pronounced in men than in women.

Conclusion: There was a negative correlation between BMD and body fat percentage in middle-aged Korean men and women with normal body weight. This association was stronger in men than in women.

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References

Beck T, Oreskovic T, Stone K, Ruff C, Ensrud K, Nevitt M . Structural adaptation to changing skeletal load in the progression toward hip fragility: the study of osteoporotic fractures. J Bone Miner Res. 2001; 16(6):1108-19. DOI: 10.1359/jbmr.2001.16.6.1108. View

Lanyon L, Skerry T . Postmenopausal osteoporosis as a failure of bone's adaptation to functional loading: a hypothesis. J Bone Miner Res. 2001; 16(11):1937-47. DOI: 10.1359/jbmr.2001.16.11.1937. View

Blum M, Harris S, Must A, Naumova E, Phillips S, Rand W . Leptin, body composition and bone mineral density in premenopausal women. Calcif Tissue Int. 2003; 73(1):27-32. DOI: 10.1007/s00223-002-1019-4. View

Hsu Y, Venners S, Terwedow H, Feng Y, Niu T, Li Z . Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr. 2006; 83(1):146-54. DOI: 10.1093/ajcn/83.1.146. View

Choi H, Kim K, Kim K, Hur N, Rhee Y, Han D . Relationship between visceral adiposity and bone mineral density in Korean adults. Calcif Tissue Int. 2010; 87(3):218-25. DOI: 10.1007/s00223-010-9398-4. View

Saarelainen J, Honkanen R, Kroger H, Tuppurainen M, Jurvelin J, Niskanen L . Body fat distribution is associated with lumbar spine bone density independently of body weight in postmenopausal women. Maturitas. 2011; 69(1):86-90. DOI: 10.1016/j.maturitas.2011.02.009. View

Katzmarzyk P, Barreira T, Harrington D, Staiano A, Heymsfield S, Gimble J . Relationship between abdominal fat and bone mineral density in white and African American adults. Bone. 2011; 50(2):576-9. PMC: 3936414. DOI: 10.1016/j.bone.2011.04.012. View

Kim J, Choi H, Kim M, Shin C, Cho N . Fat mass is negatively associated with bone mineral content in Koreans. Osteoporos Int. 2011; 23(7):2009-16. DOI: 10.1007/s00198-011-1808-6. View

Braun T, Schett G . Pathways for bone loss in inflammatory disease. Curr Osteoporos Rep. 2012; 10(2):101-8. DOI: 10.1007/s11914-012-0104-5. View

10.

Kim M, Han K, Kwon H, Song K, Yim H, Lee W . Normal weight obesity in Korean adults. Clin Endocrinol (Oxf). 2013; 80(2):214-20. DOI: 10.1111/cen.12162. View

11.

Shin D, Kim S, Kim K, Park S . Importance of fat mass and lean mass on bone health in men: the Fourth Korean National Health and Nutrition Examination Survey (KNHANES IV). Osteoporos Int. 2013; 25(2):467-74. DOI: 10.1007/s00198-013-2412-8. View

12.

Reid I, Evans M, Ames R . Volumetric bone density of the lumbar spine is related to fat mass but not lean mass in normal postmenopausal women. Osteoporos Int. 1994; 4(6):362-7. DOI: 10.1007/BF01622199. View