Long-term Effects of Smallpox Vaccination on Expression of the HIV-1 Co-receptor CCR5 in Women

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Nov 16

PMID 30440008

Citations 2

Authors

K B Beck

B L Honge

J S Olesen

M S Petersen

S Jespersen

C Wejse

Z J da Silva

C Medina

D D S Te

B K Moeller

C S Benn

P Aaby

C Erikstrup

Affiliations

Soon will be listed here.

Abstract

Background: Smallpox vaccinations were stopped globally in 1980. Recent studies have shown that in women, being smallpox vaccinated was associated with a reduced risk of HIV infection compared with not being smallpox vaccinated. At the initial infection, HIV-1 most often uses CCR5 as a co-receptor to infect the T-lymphocytes. We therefore investigated whether smallpox vaccination is associated with a down-regulation of CCR5 on the surface of peripheral T-lymphocytes in healthy women in Guinea-Bissau.

Methods: We included HIV seronegative women from Bissau, Guinea-Bissau, born before 1974, with and without a smallpox vaccination scar. Blood samples were stabilised in a TransFix buffer solution and stained for flow cytometry according to a T-cell maturation profile.

Results: Ninety-seven women were included in the study; 52 with a smallpox vaccination scar and 45 without a scar. No association between smallpox vaccination scar and CCR5 expression was found in any T-lymphocyte subtype.

Conclusion: Among HIV seronegative women, being smallpox vaccinated more than 40 years ago was not associated with a down-regulation of CCR5 receptors on the surface of peripheral T-lymphocytes.

Citing Articles

Heterologous Immunity: Role in Natural and Vaccine-Induced Resistance to Infections.

Agrawal B Front Immunol. 2019; 10:2631.

PMID: 31781118 PMC: 6856678. DOI: 10.3389/fimmu.2019.02631.

Phase-out of smallpox vaccination and the female/male HIV-1 prevalence ratio: an ecological study from Guinea-Bissau.

Rieckmann A, Villumsen M, Honge B, Sorup S, Rodrigues A, da Silva Z BMJ Open. 2019; 9(10):e031415.

PMID: 31666269 PMC: 6830606. DOI: 10.1136/bmjopen-2019-031415.

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