Instrumental Variables in the Evaluation of Diagnostic Test Procedures when the True Disease State is Unknown

Overview

Journal Stat Med

Publisher Wiley

Specialty Public Health

Date 1988 Jul 1

PMID 3043622

Citations 6

Authors

N J Nagelkerke

V Fidler

M Buwalda

Affiliations

Soon will be listed here.

Abstract

We explore the estimation of sensitivity and specificity of diagnostic tests when the true disease state is unknown. Instrumental variables which subdivide the patient population are used. A logistic model, relating these instrumental variables to the (unknown) true disease state is proposed. It is shown that this procedure allows the goodness-of-fit to the resulting model to be tested.

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