Self-Folding Hybrid Graphene Skin for 3D Biosensing

Overview

Journal Nano Lett

Publisher American Chemical Society

Specialty Biotechnology

Date 2018 Nov 16

PMID 30433789

Citations 12

Authors

Weinan Xu

Santosh K Paidi

Zhao Qin

Qi Huang

Chi-Hua Yu

Jayson V Pagaduan

Markus J Buehler

Ishan Barman

David H Gracias

Affiliations

Soon will be listed here.

Abstract

Biological samples such as cells have complex three-dimensional (3D) spatio-molecular profiles and often feature soft and irregular surfaces. Conventional biosensors are based largely on 2D and rigid substrates, which have limited contact area with the entirety of the surface of biological samples making it challenging to obtain 3D spatially resolved spectroscopic information, especially in a label-free manner. Here, we report an ultrathin, flexible skinlike biosensing platform that is capable of conformally wrapping a soft or irregularly shaped 3D biological sample such as a cancer cell or a pollen grain, and therefore enables 3D label-free spatially resolved molecular spectroscopy via surface-enhanced Raman spectroscopy (SERS). Our platform features an ultrathin thermally responsive poly( N-isopropylacrylamide)-graphene-nanoparticle hybrid skin that can be triggered to self-fold and wrap around 3D micro-objects in a conformal manner due to its superior flexibility. We highlight the utility of this 3D biosensing platform by spatially mapping the 3D molecular signatures of a variety of microparticles including silica microspheres, spiky pollen grains, and human breast cancer cells.

Citing Articles

Mechanically-Guided 3D Assembly for Architected Flexible Electronics.

Bo R, Xu S, Yang Y, Zhang Y Chem Rev. 2023; 123(18):11137-11189.

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Delamination from an adhesive sphere: Curvature-induced dewetting versus buckling.

Box F, Domino L, Outerelo Corvo T, Adda-Bedia M, Demery V, Vella D Proc Natl Acad Sci U S A. 2023; 120(12):e2212290120.

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Stimulus-Responsive Ultrathin Films for Bioapplications: A Concise Review.

Benelmekki M, Kim J Molecules. 2023; 28(3).

PMID: 36770701 PMC: 9921802. DOI: 10.3390/molecules28031020.

Engineered Two-Dimensional Nanostructures as SERS Substrates for Biomolecule Sensing: A Review.

Jebakumari K, Murugasenapathi N, Palanisamy T Biosensors (Basel). 2023; 13(1).

PMID: 36671937 PMC: 9855472. DOI: 10.3390/bios13010102.

Soft shape-programmable surfaces by fast electromagnetic actuation of liquid metal networks.

Ni X, Luan H, Kim J, Rogge S, Bai Y, Kwak J Nat Commun. 2022; 13(1):5576.

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