Influence of Polycystic Ovary Syndrome on the Periodontal Health of Indian Women Visiting a Secondary Health Care Centre

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2018 Nov 16

PMID 30430337

Citations 11

Authors

Manjusha Varadan

Pratibha Gopalkrishna

Parvati V Bhat

Shobha U Kamath

Krithishree S

Thriveni G K

Santhosh Kumar

Affiliations

Soon will be listed here.

Abstract

Objectives: Periodontal disease and polycystic ovary syndrome (PCOS) share risk factors like obesity, insulin resistance, and dyslipidemia, along with evidence of chronic inflammation in the two conditions. Evaluating the influence of PCOS on periodontal health would, therefore, identify a possible association.

Materials And Methods: Sixty women, divided into equal groups of PCOS and healthy patients, were clinically examined for periodontal parameters like probing depth (PD), plaque index (PI), modified gingival index (mGI), and bleeding on probing (BOP). Fasting blood sugar (FBS), insulin (FI), triglycerides (TG), and free testosterone along with serum and gingival crevicular fluid (GCF) levels of malondialdehyde (MDA) and myeloperoxidase (MPO) were the biochemical parameters evaluated.

Results: Women with PCOS had statistically significant differences in mGI, PI, testosterone, FBS, and TG when compared with healthy women (p < 0.05). MDA levels in serum and GCF between women with PCOS and controls were also significantly different. BOP and mGI showed a moderate positive correlation (r = 0.45 and 0.44) with serum levels of MDA. Relatively greater gingival inflammation was observed in patients with PCOS compared to healthy controls, independent of the risk factors present.

Conclusion: PCOS seemed to have an impact on gingival inflammation, in addition to the effect of dental plaque and other local factors in the oral cavity, in PCOS patients when compared with healthy individuals.

Clinical Relevance: Women diagnosed with PCOS may have probabaility of co-existing gingival inflammation. Therefore, emphasis on medical treatment for PCOS and periodic screening for periodontal disease may be warranted.

Citing Articles

Assessment of the Validity and Quality of Polycystic Ovarian Syndrome (PCOS) Screening Tools Available for Women Globally: A Systematic Review.

Sacca L, Lobaina D, Knopf E, Burgoa S, Jimenez S, Okwaraji G Clin Pract. 2024; 14(5):1625-1649.

PMID: 39311281 PMC: 11417729. DOI: 10.3390/clinpract14050131.

Causal relationship between PCOS and related sex hormones with oral inflammatory diseases: a bidirectional Mendelian randomization study.

Min Q, Chen Y, Geng H, Gao Q, Zhang X, Xu M Front Endocrinol (Lausanne). 2024; 14:1282056.

PMID: 38264282 PMC: 10803436. DOI: 10.3389/fendo.2023.1282056.

Bidirectional association between polycystic ovary syndrome and periodontal diseases.

Dou Y, Xin J, Zhou P, Tang J, Xie H, Fan W Front Endocrinol (Lausanne). 2023; 14:1008675.

PMID: 36755917 PMC: 9899846. DOI: 10.3389/fendo.2023.1008675.

Bone markers and bone mineral density associates with periodontitis in females with poly-cystic ovarian syndrome.

Zia A, Hakim S, Khan A, Bey A, Ateeq H, Parveen S J Bone Miner Metab. 2022; 40(3):487-497.

PMID: 35072780 DOI: 10.1007/s00774-021-01302-6.

Serum Inflammatory and Prooxidant Marker Levels in Different Periodontal Disease Stages.

Andreu R, Santos-Del-Riego S, Payri F Healthcare (Basel). 2021; 9(8).

PMID: 34442206 PMC: 8391602. DOI: 10.3390/healthcare9081070.

References

Yamalik N, Caglayan F, Kilinc K, Kilinc A, Tumer C . The importance of data presentation regarding gingival crevicular fluid myeloperoxidase and elastase-like activity in periodontal disease and health status. J Periodontol. 2000; 71(3):460-7. DOI: 10.1902/jop.2000.71.3.460. View

SILNESS J, Loe H . PERIODONTAL DISEASE IN PREGNANCY. II. CORRELATION BETWEEN ORAL HYGIENE AND PERIODONTAL CONDTION. Acta Odontol Scand. 1964; 22:121-35. DOI: 10.3109/00016356408993968. View

. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2003; 19(1):41-7. DOI: 10.1093/humrep/deh098. View

Wei P, Ho K, Ho Y, Wu Y, Yang Y, Tsai C . The investigation of glutathione peroxidase, lactoferrin, myeloperoxidase and interleukin-1beta in gingival crevicular fluid: implications for oxidative stress in human periodontal diseases. J Periodontal Res. 2004; 39(5):287-93. DOI: 10.1111/j.1600-0765.2004.00744.x. View

Burt B . Position paper: epidemiology of periodontal diseases. J Periodontol. 2005; 76(8):1406-19. DOI: 10.1902/jop.2005.76.8.1406. View

Bostanci N, Tunc Ilgenli , Emingil G, Afacan B, Han B, Toz H . Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio. J Clin Periodontol. 2007; 34(5):370-6. DOI: 10.1111/j.1600-051X.2007.01061.x. View

Akalin F, Baltacioglu E, Alver A, Karabulut E . Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis. J Clin Periodontol. 2007; 34(7):558-65. DOI: 10.1111/j.1600-051X.2007.01091.x. View

Farshchi H, Rane A, Love A, Kennedy R . Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management. J Obstet Gynaecol. 2007; 27(8):762-73. DOI: 10.1080/01443610701667338. View

Kuscu N, Var A . Oxidative stress but not endothelial dysfunction exists in non-obese, young group of patients with polycystic ovary syndrome. Acta Obstet Gynecol Scand. 2009; 88(5):612-7. DOI: 10.1080/00016340902859315. View

10.

Schindhelm R, van der Zwan L, Teerlink T, Scheffer P . Myeloperoxidase: a useful biomarker for cardiovascular disease risk stratification?. Clin Chem. 2009; 55(8):1462-70. DOI: 10.1373/clinchem.2009.126029. View

11.

Bullon P, Morillo J, Ramirez-Tortosa M, Quiles J, Newman H, Battino M . Metabolic syndrome and periodontitis: is oxidative stress a common link?. J Dent Res. 2009; 88(6):503-18. DOI: 10.1177/0022034509337479. View

12.

Dursun E, Akalin F, Guncu G, Cinar N, Yazgan Aksoy D, Tozum T . Periodontal disease in polycystic ovary syndrome. Fertil Steril. 2010; 95(1):320-3. DOI: 10.1016/j.fertnstert.2010.07.1052. View

13.

Kurdoglu Z, Ozkol H, Tuluce Y, Koyuncu I . Oxidative status and its relation with insulin resistance in young non-obese women with polycystic ovary syndrome. J Endocrinol Invest. 2011; 35(3):317-21. DOI: 10.3275/7682. View

14.

Nidhi R, Padmalatha V, Nagarathna R, Amritanshu R . Prevalence of polycystic ovarian syndrome in Indian adolescents. J Pediatr Adolesc Gynecol. 2011; 24(4):223-7. DOI: 10.1016/j.jpag.2011.03.002. View

15.

Kurdoglu Z, Ozkol H, Kurdoglu M . Serum myeloperoxidase and adenosine deaminase activities in polycystic ovary syndrome. Gynecol Endocrinol. 2011; 28(2):115-8. DOI: 10.3109/09513590.2011.583959. View

16.

Nair M, Pappachan P, Balakrishnan S, Leena M, George B, Russell P . Menstrual irregularity and poly cystic ovarian syndrome among adolescent girls--a 2 year follow-up study. Indian J Pediatr. 2011; 79 Suppl 1:S69-73. DOI: 10.1007/s12098-011-0432-y. View

17.

Duleba A, Dokras A . Is PCOS an inflammatory process?. Fertil Steril. 2011; 97(1):7-12. PMC: 3245829. DOI: 10.1016/j.fertnstert.2011.11.023. View

18.

Ozcaka O, Ceyhan B, Akcali A, Bicakci N, Lappin D, Buduneli N . Is there an interaction between polycystic ovary syndrome and gingival inflammation?. J Periodontol. 2012; 83(12):1529-37. DOI: 10.1902/jop.2012.110588. View

19.

Marchetti E, Monaco A, Procaccini L, Mummolo S, Gatto R, Tete S . Periodontal disease: the influence of metabolic syndrome. Nutr Metab (Lond). 2012; 9(1):88. PMC: 3499456. DOI: 10.1186/1743-7075-9-88. View

20.

Li R, Zhang Q, Yang D, Li S, Lu S, Wu X . Prevalence of polycystic ovary syndrome in women in China: a large community-based study. Hum Reprod. 2013; 28(9):2562-9. DOI: 10.1093/humrep/det262. View