Revisiting Bacterial Ubiquitin Ligase Effectors: Weapons for Host Exploitation

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2018 Nov 16

PMID 30428531

Citations 14

Authors

Antonio Pisano

Francesco Albano

Eleonora Vecchio

Maurizio Renna

Giuseppe Scala

Ileana Quinto

Giuseppe Fiume

Affiliations

Soon will be listed here.

Abstract

Protein ubiquitylation plays a central role in eukaryotic cell physiology. It is involved in several regulatory processes, ranging from protein folding or degradation, subcellular localization of proteins, vesicular trafficking and endocytosis to DNA repair, cell cycle, innate immunity, autophagy, and apoptosis. As such, it is reasonable that pathogens have developed a way to exploit such a crucial system to enhance their virulence against the host. Hence, bacteria have evolved a wide range of effectors capable of mimicking the main players of the eukaryotic ubiquitin system, in particular ubiquitin ligases, by interfering with host physiology. Here, we give an overview of this topic and, in particular, we detail and discuss the mechanisms developed by pathogenic bacteria to hijack the host ubiquitination system for their own benefit.

Citing Articles

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