Distinctive Semantic Features in the Healthy Adult Brain

Overview

Journal Cogn Affect Behav Neurosci

Publisher Springer

Specialties Neurology
Social Sciences

Date 2018 Nov 15

PMID 30426310

Authors

Megan Reilly

Natalya Machado

Sheila E Blumstein

Affiliations

Soon will be listed here.

Abstract

The role of semantic features, which are distinctive (e.g., a zebra's stripes) or shared (e.g. has four legs) for accessing a concept, has been studied in detail in early neurodegenerative disease such as semantic dementia (SD). However, potential neural underpinnings of such processing have not been studied in healthy adults. The current study examines neural activation patterns using fMRI while participants completed a feature verification task, in which they identified shared or distinctive semantic features for a set of natural kinds and man-made artifacts. The results showed that the anterior temporal lobe bilaterally is an important area for processing distinctive features, and that this effect is stronger within natural kinds than man-made artifacts. These findings provide converging evidence from healthy adults that is consistent with SD research, and support a model of semantic memory in which patterns of specificity of semantic information can partially explain differences in neural activation between categories.

References

Ilshire C, McCarthy R . Evidence for a context-sensitive word retrieval disorder in a case of nonfluent aphasia. Cogn Neuropsychol. 2010; 19(2):165-86. DOI: 10.1080/02643290143000169. View

Libon D, Rascovsky K, Powers J, Irwin D, Boller A, Weinberg D . Comparative semantic profiles in semantic dementia and Alzheimer's disease. Brain. 2013; 136(Pt 8):2497-509. PMC: 3722350. DOI: 10.1093/brain/awt165. View

Davey J, Thompson H, Hallam G, Karapanagiotidis T, Murphy C, De Caso I . Exploring the role of the posterior middle temporal gyrus in semantic cognition: Integration of anterior temporal lobe with executive processes. Neuroimage. 2016; 137:165-177. PMC: 4927261. DOI: 10.1016/j.neuroimage.2016.05.051. View

Randall B, Moss H, Rodd J, Greer M, Tyler L . Distinctiveness and correlation in conceptual structure: behavioral and computational studies. J Exp Psychol Learn Mem Cogn. 2004; 30(2):393-406. DOI: 10.1037/0278-7393.30.2.393. View

Rogers T, Ivanoiu A, Patterson K, Hodges J . Semantic memory in Alzheimer's disease and the frontotemporal dementias: a longitudinal study of 236 patients. Neuropsychology. 2006; 20(3):319-35. DOI: 10.1037/0894-4105.20.3.319. View

Bonner M, Price A . Where is the anterior temporal lobe and what does it do?. J Neurosci. 2013; 33(10):4213-5. PMC: 3632379. DOI: 10.1523/JNEUROSCI.0041-13.2013. View

Olson I, McCoy D, Klobusicky E, Ross L . Social cognition and the anterior temporal lobes: a review and theoretical framework. Soc Cogn Affect Neurosci. 2012; 8(2):123-33. PMC: 3575728. DOI: 10.1093/scan/nss119. View

Righi G, Blumstein S, Mertus J, Worden M . Neural systems underlying lexical competition: an eye tracking and fMRI study. J Cogn Neurosci. 2009; 22(2):213-24. PMC: 2857934. DOI: 10.1162/jocn.2009.21200. View

Hodges J, Patterson K, Oxbury S, Funnell E . Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. Brain. 1992; 115 ( Pt 6):1783-806. DOI: 10.1093/brain/115.6.1783. View

10.

Santi A, Raposo A, Frade S, Marques J . Concept typicality responses in the semantic memory network. Neuropsychologia. 2016; 93(Pt A):167-175. DOI: 10.1016/j.neuropsychologia.2016.10.012. View

11.

L Seghier M . The angular gyrus: multiple functions and multiple subdivisions. Neuroscientist. 2012; 19(1):43-61. PMC: 4107834. DOI: 10.1177/1073858412440596. View

12.

Brysbaert M, New B . Moving beyond Kucera and Francis: a critical evaluation of current word frequency norms and the introduction of a new and improved word frequency measure for American English. Behav Res Methods. 2009; 41(4):977-90. DOI: 10.3758/BRM.41.4.977. View

13.

Nagel I, Schumacher E, Goebel R, DEsposito M . Functional MRI investigation of verbal selection mechanisms in lateral prefrontal cortex. Neuroimage. 2008; 43(4):801-7. PMC: 2612124. DOI: 10.1016/j.neuroimage.2008.07.017. View

14.

Rogers T, Patterson K, Jefferies E, Lambon Ralph M . Disorders of representation and control in semantic cognition: Effects of familiarity, typicality, and specificity. Neuropsychologia. 2015; 76:220-39. PMC: 4582808. DOI: 10.1016/j.neuropsychologia.2015.04.015. View

15.

Jefferies E, Lambon Ralph M . Semantic impairment in stroke aphasia versus semantic dementia: a case-series comparison. Brain. 2006; 129(Pt 8):2132-47. DOI: 10.1093/brain/awl153. View

16.

Rice G, Hoffman P, Lambon Ralph M . Graded specialization within and between the anterior temporal lobes. Ann N Y Acad Sci. 2015; 1359:84-97. PMC: 4982095. DOI: 10.1111/nyas.12951. View

17.

Lambon Ralph M, Pobric G, Jefferies E . Conceptual knowledge is underpinned by the temporal pole bilaterally: convergent evidence from rTMS. Cereb Cortex. 2008; 19(4):832-8. DOI: 10.1093/cercor/bhn131. View

18.

Ross L, Olson I . Social cognition and the anterior temporal lobes. Neuroimage. 2009; 49(4):3452-62. PMC: 2818559. DOI: 10.1016/j.neuroimage.2009.11.012. View

19.

Garrard P, Lambon Ralph M, Patterson K, Pratt K, Hodges J . Semantic feature knowledge and picture naming in dementia of Alzheimer's type: a new approach. Brain Lang. 2005; 93(1):79-94. DOI: 10.1016/j.bandl.2004.08.003. View

20.

Binney R, Embleton K, Jefferies E, Parker G, Lambon Ralph M . The ventral and inferolateral aspects of the anterior temporal lobe are crucial in semantic memory: evidence from a novel direct comparison of distortion-corrected fMRI, rTMS, and semantic dementia. Cereb Cortex. 2010; 20(11):2728-38. DOI: 10.1093/cercor/bhq019. View