V/VCO Slope in Lean and Overweight Women and Its Relationship to Lean Leg Mass

Overview

Journal Int J Cardiol Heart Vasc

Date 2018 Nov 15

PMID 30426069

Citations 2

Authors

Manda L Keller-Ross

Daniel P Chantigian

Nicholas Evanoff

Anne E Bantle

Donald R Dengel

Lisa S Chow

Affiliations

Soon will be listed here.

Abstract

Methods: Gas exchange and ventilation were collected during a treadmill peak oxygen uptake test (VO) in 40 women [26 OWS (29 ± 7 yrs., mean ± SD), 7 OWTR (33 ± 5 yrs) and 7 LTR (26 ± 6 yrs)]. Body composition was measured by dual X-ray absorptiometry.

Results: VO was highest in LTR (46.6 ± 8 ml/kg/min) compared with OWTR (38.1 ± 4.9 ml/kg/min) and OWS women (25.3 ± 4.8 ml/kg/min, p < 0.05). Lean leg mass was highest in OWTR and lowest in LTR women (p < 0.05). V/VCO was similar between groups (p > 0.05). Higher lean leg mass was associated with lower V/VCO in overweight women (OWS + OWTR: r = -0.55, p < 0.001), contrasting with higher V/VCO in LTR women (r = 0.86, p < 0.001).

Conclusions: These findings suggest V/VCO may not differentiate between low and high cardiorespiratory fitness in healthy individuals and muscle mass may play a role in determining the V/VCO, independent of disease.

Citing Articles

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References

Pelosi P, Croci M, Ravagnan I, Cerisara M, Vicardi P, Lissoni A . Respiratory system mechanics in sedated, paralyzed, morbidly obese patients. J Appl Physiol (1985). 1997; 82(3):811-8. DOI: 10.1152/jappl.1997.82.3.811. View

Trappe S, Trappe T, Gallagher P, Harber M, Alkner B, Tesch P . Human single muscle fibre function with 84 day bed-rest and resistance exercise. J Physiol. 2004; 557(Pt 2):501-13. PMC: 1665105. DOI: 10.1113/jphysiol.2004.062166. View

Arena R, Myers J, Aslam S, Varughese E, Peberdy M . Peak VO2 and VE/VCO2 slope in patients with heart failure: a prognostic comparison. Am Heart J. 2004; 147(2):354-60. DOI: 10.1016/j.ahj.2003.07.014. View

Ogden C, Carroll M, Fryar C, Flegal K . Prevalence of Obesity Among Adults and Youth: United States, 2011-2014. NCHS Data Brief. 2015; (219):1-8. View

Kaufman C, Kelly A, Kaiser D, Steinberger J, Dengel D . Aerobic-exercise training improves ventilatory efficiency in overweight children. Pediatr Exerc Sci. 2007; 19(1):82-92. DOI: 10.1123/pes.19.1.82. View

Arena R, Myers J, Aslam S, Varughese E, Peberdy M . Technical considerations related to the minute ventilation/carbon dioxide output slope in patients with heart failure. Chest. 2003; 124(2):720-7. DOI: 10.1378/chest.124.2.720. View

Keller-Ross M, Johnson B, Carter R, Joyner M, Eisenach J, Curry T . Improved Ventilatory Efficiency with Locomotor Muscle Afferent Inhibition is Strongly Associated with Leg Composition in Heart Failure. Int J Cardiol. 2015; 202:159-66. PMC: 4656052. DOI: 10.1016/j.ijcard.2015.08.212. View

Cohn J, Rector T . Prognosis of congestive heart failure and predictors of mortality. Am J Cardiol. 1988; 62(2):25A-30A. DOI: 10.1016/s0002-9149(88)80081-x. View

deJong A, Gallagher M, Sandberg K, Lillystone M, Spring T, Franklin B . Peak oxygen consumption and the minute ventilation/carbon dioxide production relation slope in morbidly obese men and women: influence of subject effort and body mass index. Prev Cardiol. 2008; 11(2):100-5. DOI: 10.1111/j.1751-7141.2008.07591.x. View

10.

Campo A, Fruhbeck G, Zulueta J, Iriarte J, Seijo L, Alcaide A . Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients. Eur Respir J. 2007; 30(2):223-31. DOI: 10.1183/09031936.00115006. View

11.

Pankow W, Podszus T, Gutheil T, Penzel T, Peter J, von Wichert P . Expiratory flow limitation and intrinsic positive end-expiratory pressure in obesity. J Appl Physiol (1985). 1998; 85(4):1236-43. DOI: 10.1152/jappl.1998.85.4.1236. View

12.

Trappe T, Burd N, Louis E, Lee G, Trappe S . Influence of concurrent exercise or nutrition countermeasures on thigh and calf muscle size and function during 60 days of bed rest in women. Acta Physiol (Oxf). 2007; 191(2):147-59. DOI: 10.1111/j.1748-1716.2007.01728.x. View

13.

Tonks K, Coster A, Christopher M, Chaudhuri R, Xu A, Gagnon-Bartsch J . Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans. Obesity (Silver Spring). 2016; 24(4):908-16. PMC: 6585800. DOI: 10.1002/oby.21448. View

14.

ODonnell C, Tankersley C, Polotsky V, Schwartz A, Smith P . Leptin, obesity, and respiratory function. Respir Physiol. 2000; 119(2-3):163-70. DOI: 10.1016/s0034-5687(99)00111-5. View

15.

Coggan A, Spina R, King D, Rogers M, Brown M, Nemeth P . Skeletal muscle adaptations to endurance training in 60- to 70-yr-old men and women. J Appl Physiol (1985). 1992; 72(5):1780-6. DOI: 10.1152/jappl.1992.72.5.1780. View

16.

Babb T, Buskirk E, Hodgson J . Exercise end-expiratory lung volumes in lean and moderately obese women. Int J Obes. 1989; 13(1):11-9. View

17.

Blair S, Kampert J, Kohl 3rd H, Barlow C, Macera C, Paffenbarger Jr R . Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women. JAMA. 1996; 276(3):205-10. View

18.

Martin T, Sanders M . Chronic alveolar hypoventilation: a review for the clinician. Sleep. 1995; 18(8):617-34. DOI: 10.1093/sleep/18.8.617. View

19.

Guazzi M . Abnormalities in cardiopulmonary exercise testing ventilatory parameters in heart failure: pathophysiology and clinical usefulness. Curr Heart Fail Rep. 2014; 11(1):80-7. DOI: 10.1007/s11897-013-0183-3. View

20.

Balady G, Arena R, Sietsema K, Myers J, Coke L, Fletcher G . Clinician's Guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation. 2010; 122(2):191-225. DOI: 10.1161/CIR.0b013e3181e52e69. View